39684-46-3

Upstream product

• 67-62-9 O-Methylhydroxylamin 
• 611-73-4 Benzoylformic acid 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 55104-63-7 ethyl 2-(pyridin-2-yl)-2-oxoacetate 
• 39684-40-7 (E)-methyl 2-(methoxyimino)-2-phenylacetate 
• 171249-81-3 ethyl α-methoxyiminophenylacetate 
• 40785-55-5 (2-hydroxyphenyl)-glyoxylic acid ethyl ester 
• 2935-35-5 (S)-2-phenylglycine 
• 70091-75-7 ethyl 2-(4-nitrophenyl)-2-oxoacetate 

Downstream Products

• 39684-40-7 (E)-methyl 2-(methoxyimino)-2-phenylacetate 
• 39684-39-4 (Z)-methyl 2-(methoxyimino)-2-phenylacetate 

Relevant academic research and scientific papers

Efficient synthesis of (Z)- and (E)-methyl 2-(methoxyimino)-2-phenylacetate

Direct oximation of 2-oxo-2-phenylacetate (3) gave the (Z)-methyl 2-(methoxyimino)-2-phenylacetate (1) in 71% yield, while the E oxime 2 was prepared from 3 in 65% yield via oxime isomerization of 2-(methoxyimino)-2-phenylacetic acid (5). Computational st

Combinatorial synthesis through disulfide exchange: Discovery of potent psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA)

Psammaplin A is a symmetrical bromotyrosine-derived disulfide natural product isolated from the Psammaplysilla sponge, which exhibits in vitro antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). Inspired by the structure of this marine natural product, a combinatorial scrambling strategy for the construction of heterodimeric disulfide analogues was developed and applied to the construction of a 3828-membered library starting from 88 homodimeric disulfides. These psammaplin A analogues were screened directly against various gram positive bacterial strains leading to the discovery of a series of potent antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA). Among the most active leads derived from these studies are compounds 104, 105, 113, 115, 123, and 128. The present, catalytically-induced, disulfide exchange strategy may be extendable to other types of building blocks bearing thiol groups facilitating the construction of diverse discovery-oriented combinatorial libraries.

13-substituted milbemycin derivatives, their preparation and their use

13-Substituted milbemycin derivatives having the formula (I): STR1 wherein: R1 is methyl, ethyl, isopropyl or sec-butyl; R2 is hydrogen or alkyl; X is (α-hydroxyimino- or α-alkoxyimino-substituted)-arylmethyl or (α-hydroxyimino- or α-alkoxyimino-substituted)-heterocyclylmethyl, N-substituted-aminophenyl or N-substituted-aminophenoxy; m is 0 or 1; and n is 0 or 1; are valuable as agricultural and horticultural anthelmintic, acaricidal and insecticidal agents.