39696-89-4Relevant academic research and scientific papers
A Sterically Congested α-Cyanoamine as a Cyanating Reagent: Cyanation of Acetals and Orthoesters
Kotani, Shunsuke,Sakamoto, Midori,Osakama, Kazuki,Nakajima, Makoto
, p. 6606 - 6609 (2015)
The cyanation of acetals and orthoesters by using a sterically congested α-cyanoamine as a cyanating reagent was investigated. The α-cyanoamine effectively facilitated cyanation in the presence of trichlorosilyl triflate to produce a variety of cyanated adducts in excellent yields. Analysis of the reaction mixture by 1H NMR spectroscopy revealed that trichlorosilyl triflate produced an oxocarbenium cation species as an intermediate.
2-phenylethylamine derivatives
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, (2008/06/13)
Compounds of formula (I): STR1 or a pharmaceutically acceptable salt, ester or amide thereof, wherein: Ar is benzofuran-2-yl, or phenyl optionally substituted by groups R1 and/or R2 wherein R1 is halogen, trifluoromethyl or hydroxy and R2 is halogen; R3 is hydrogen or methyl; X is --O(CH2)a CO2 H, --O(CH2)bM or --CO2 H in which a is an integer from 1 to 6, b is an integer from 2 to 7, M is hydroxy, C1-6 alkoxy, phenyl C1-6 alkoxy, or --NR4 R5 in which R4 and R5 are each hydrogen or C1-6 alkyl or together form a five or six membered heterocyclic ring; Y is C2-6 straight or branched alkylene, with at least two carbon atoms between the --O-- and --OH; and n is 1 or 2, having anti-obesity and/or anti-hyperglycaemic activity, processes for their preparation and their pharmaceutical use.
