3970-68-1

Basic information

• Product Name: 4-METHYLPIPERIDIN-4-OL
• Synonyms: 4-METHYLPIPERIDIN-4-OL;4-Hydroxy-4-methylpiperidine;4-Hydroxy-4-methylpiperid...;4-Methyl-4-piperidinol;4-pipecolin-4-ol;4-METHYLPIPERIDIN-4-OL hcl;4-Piperidinol, 4-Methyl-;4-Methyl-4-hydroxypiperidine
• CAS NO: 3970-68-1
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.18
• Mol File: 3970-68-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 184.425 °C at 760 mmHg
• Flash Point: 79.471 °C
• Appearance: /
• Density: 0.977 g/cm³
• Vapor Pressure: 0.209mmHg at 25°C
• Refractive Index: 1.465
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 15.01±0.20(Predicted)
• CAS DataBase Reference: 4-METHYLPIPERIDIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLPIPERIDIN-4-OL(3970-68-1)
• EPA Substance Registry System: 4-METHYLPIPERIDIN-4-OL(3970-68-1)

Safety Data

• Hazardous Substances Data: 3970-68-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H13NO/c1-6(8)2-4-7-5-3-6/h7-8H,2-5H2,1H3

Upstream product

• 3970-66-9 1-benzyl-4-methyl-piperidin-4-ol 
• 626-58-4 4-methylpiperidin 
• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 406235-30-1 tert-butyl 4-hydroxy-4-methylpiperidine-1-carboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 169750-57-6 benzyl 4-hydroxy-4-methylpiperidine-1-carboxylate 

Downstream Products

• 1197848-68-2 1-(2-((6-chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)methylamino)pyrimidin-4-yl)-4-methylpiperidin-4-ol 
• 868609-98-7 1-[(E)-3-(4-bromo-phenyl)-but-2-enyl]-4-methyl-piperidin-4-ol 
• 868609-35-2 1-[3-(4-iodo-phenyl)-cyclohex-2-enyl]-4-methyl-piperidin-4-ol 
• 1443244-49-2 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-((1S,4R)-4-[3-(4-methyl-4-triisopropylsilanyloxy-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl)-urea 
• 1443240-64-9 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-{(1S,4R)-4-[3-(4-hydroxy-4-methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea 
• 1445792-92-6 C₁₉H₁₈F₄N₂O₄S 
• 1445790-90-8 C₁₉H₁₉ClF₂N₂O₄S 
• 19980-01-9 (4-hydroxy-4-methylpiperidin-1-yl)(phenyl)methanone 
• 1464158-41-5 (4-bromophenyl)(4-hydroxy-4-methylpiperidin-1-yl)methanone 

Relevant articles and documents

PYRIDINYL SULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The invention relates to new pyridinyl sulfonamide derivatives of the formula (I) wherein R1, A and n are as defined in the description and claims, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

Remote C(sp3)-H Oxygenation of Protonated Aliphatic Amines with Potassium Persulfate

This letter describes the development of a method for selective remote C(sp3)-H oxygenation of protonated aliphatic amines using aqueous potassium persulfate. Protonation serves to deactivate the proximal C(sp3)-H bonds of the amine substrates and also renders the amines soluble in the aqueous medium. These reactions proceed under relatively mild conditions (within 2 h at 80 °C with amine as limiting reagent) and do not require a transition metal catalyst. This method is applicable to a variety of types of C(sp3)-H bonds, including 3°, 2°, and benzylic C-H sites in primary, secondary, and tertiary amine substrates.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.