3971-48-0

Basic information

• Product Name: 1,5-anhydro-D-galactitol
• Synonyms: 1,5-anhydro-D-galactitol
• CAS NO: 3971-48-0
• Molecular Weight: 164.158
• Mol File: 3971-48-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 114-115 °C
• Boiling Point: 376.8±42.0 °C(Predicted)
• Density: 1.533±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1,5-anhydro-D-galactitol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-anhydro-D-galactitol(3971-48-0)
• EPA Substance Registry System: 1,5-anhydro-D-galactitol(3971-48-0)

Safety Data

• Hazardous Substances Data: 3971-48-0(Hazardous Substances Data)

Usage

Chemical compound

1,5-anhydro-D-galactitol is a chemical compound that is a derivative of galactose.

Sugar alcohol

It is a sugar alcohol that is found in small amounts in some natural sources, such as certain fruits and vegetables.

Therapeutic effects

1,5-anhydro-D-galactitol has been studied for its potential therapeutic effects in the treatment of certain medical conditions, such as diabetes and inflammation.

Role in disease

It has been investigated for its role in the development and progression of certain diseases, including cancer.

Ongoing research

Research on this compound is ongoing, and further studies are needed to fully understand its potential benefits and risks for human health.

Upstream product

• 7464-38-2 2-naphthyl 2,3,4,6-tetra-O-acetyl-1-thio-β-D-galactopyranoside 
• 59-23-4 D-Galactose 
• 19200-39-6 N,N-diethyl β-D-galactopyranosyl dithiocarbamate 
• 55529-70-9 per-O-trimethylsilyl-D-galactopyranoside 
• 4133-45-3 methyl 2,3,4,6-tetra-O-trimethylsilyl-α-D-galactopyranoside 
• 2296-39-1 methyl 2,3,4,6-tetrakis-O-trimethylsilyl-β-D-galactopyranoside 
• 80040-79-5 3,4,6-tri-O-benzyl-D-galactal 
• 3068-32-4 1-bromo-1-deoxy-2,3,4,6-tetra-O-acetyl-a-D-galactopyranoside 
• 162060-53-9 1,5-anhydro-3,4,6-tri-O-benzyl-D-galactitol 
• 82682-67-5 (2R,3S,4R,5S)-3,4,5-Tris-trimethylsilanyloxy-2-trimethylsilanyloxymethyl-tetrahydro-pyran 
• 13121-62-5 2,3,4,6-tetra-O-acetyl-1,5-anhydro-D-galactitol 

Downstream Products

• 85906-19-0 1,5-anhydro-2,3,4-tri-O-benzoyl-6-O-p-tolylsulfonyl-D-galactitol 
• 109010-33-5 methyl 2-O-benzoyl-4,6-O-benzylidene-α-D-galactopyranoside 
• 1204228-81-8 1,5-anhydro-4,6-O-benzylidene-D-galactitol 
• 88043-87-2 1,5-anhydro-4,6-di-O-benzoyl-D-galactitol 
• 74629-56-4 1,5-anhydro-3,4,6-tri-O-benzoyl-D-galactitol 
• 65371-05-3 1,5-anhydro-3,6-di-O-p-tolylsulfonyl-D-galactitol 
• 65371-03-1 1,5-anhydro-2,3,6-tri-O-p-tolylsulfonyl-D-galactitol 
• 65371-00-8 1,5-anhydro-2,3,4,6-tetra-O-p-tolylsulfonyl-D-galactitol 
• 85906-16-7 1,5-anhydro-6-O-p-tolylsulfonyl-D-galactitol 
• 143916-17-0 1,5-anhydro-3,4-O-isopropylidene-6-O-trityl-D-galactitol 
• 143916-18-1 2-O-acetyl-1,5-anhydro-3,4-O-isopropylidene-6-O-trityl-D-galactitol 
• 17598-82-2 L-tagatose 
• 143697-39-6 2,6-Anhydro-1,5-di-O-benzyl-3-deoxy-L-threo-hex-2-enitol 
• 143697-40-9 Methyl 1,5-di-O-benzyl-α-L-tagatopyranoside 

Relevant articles and documents

A Potent Mimetic of the Siglec-8 Ligand 6’-Sulfo-Sialyl Lewisx

Siglecs are members of the immunoglobulin gene family containing sialic acid binding N-terminal domains. Among them, Siglec-8 is expressed on various cell types of the immune system such as eosinophils, mast cells and weakly on basophils. Cross-linking of Siglec-8 with monoclonal antibodies triggers apoptosis in eosinophils and inhibits degranulation of mast cells, making Siglec-8 a promising target for the treatment of eosinophil- and mast cell-associated diseases such as asthma. The tetrasaccharide 6’-sulfo-sialyl Lewisx has been identified as a specific Siglec-8 ligand in glycan array screening. Here, we describe an extended study enlightening the pharmacophores of 6’-sulfo-sialyl Lewisx and the successful development of a high-affinity mimetic. Retaining the neuraminic acid core, the introduction of a carbocyclic mimetic of the Gal moiety and a sulfonamide substituent in the 9-position gave a 20-fold improved binding affinity. Finally, the residence time, which usually is the Achilles tendon of carbohydrate/lectin interactions, could be improved.

First protection-free protocol for synthesis of 1-deoxy sugars through glycosyl dithiocarbamate intermediates

A practical two-step synthetic process for 1-deoxy sugars has been established. The process consists of the direct introduction of a dimethyldithiocarbamate group into the anomeric center of unprotected sugars and subsequent hydrogenation in the AIBN-H3PO2-NaHCO3 system. No protecting groups are needed to synthesize 1-deoxy monosaccharides and 1-deoxy disaccharides.

Aziridine ring opening as regio- and stereoselective access to O-glycosyl amino acids and their transformation into O-glycopeptide mimetics

Glycosyl amino acid mimetics of the typical GalNAc-(1→O)-Ser/Thr motif of O-glycopeptides were synthesised. Starting from galactose a 1,5-anhydro derivative could be obtained and regio- and stereoselectively coupled to serine- or threonine-derived aziridine compounds, respectively. The corresponding Fmoc derivatives could be used to prepare two 13-mer glycopeptides of the mucin MUC1 carrying instead of Ser-2 or Th-5, the corresponding O-glcycosyl amino acid mimetics.