3972-41-6

Basic information

• Product Name: (R)-BROMOSUCCINIC ACID
• Synonyms: (R)-BROMOSUCCINIC ACID;(R)-2-broMosuccinic acid
• CAS NO: 3972-41-6
• Molecular Formula: C₄H₅BrO₄
• Molecular Weight: 196.98
• Mol File: 3972-41-6.mol
• Article Data: 35

Chemical Properties

• Melting Point: 166-167 °C
• Boiling Point: 255.1°C at 760 mmHg
• Flash Point: 108.1°C
• Appearance: /
• Density: 2.022g/cm³
• Vapor Pressure: 0.00512mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: 2-8°C
• Solubility: Acetonitrile (Slightly), Methanol (Slightly, Sonicated)
• PKA: 2.71±0.23(Predicted)
• CAS DataBase Reference: (R)-BROMOSUCCINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-BROMOSUCCINIC ACID(3972-41-6)
• EPA Substance Registry System: (R)-BROMOSUCCINIC ACID(3972-41-6)

Safety Data

• Hazardous Substances Data: 3972-41-6(Hazardous Substances Data)

Usage

Uses

(R)-2-Bromosuccinic Acid is an enantiomer of (S)-2-Bromosuccinic Acid, which?is a useful reagent to synthesize?3-mercaptopyrrolidine derivatives and alkanols.?(R)-2-Bromosuccinic Acid can be utilized to develop enantioselective HPLC separations with a chiral stationary phase and ristocetin A (a macrocyclic glycopeptide).

InChI:InChI=1/C4H5BrO4/c5-2(4(8)9)1-3(6)7/h2H,1H2,(H,6,7)(H,8,9)/t2-/m1/s1

Upstream product

• 56-84-8 L-Aspartic acid 
• 64-17-5 ethanol 
• 158706-00-4 diethyl (R)-bromosuccinate 
• 1783-96-6 (2R)-aspartic acid 
• 10035-10-6 hydrogen bromide 
• 617-45-8 aspartic Acid 

Downstream Products

• 197433-31-1 (S)-ethoxythiocarbonylmercapto-succinic acid 
• 197433-30-0 (R)-ethoxythiocarbonylmercapto-succinic acid 
• 22119-13-7 (S)-benzoylmercaptosuccinic acid 
• 22119-13-7 (R)-benzoylmercaptosuccinic acid 
• 158706-00-4 diethyl (R)-bromosuccinate 
• 158705-99-8 (S)-diethyl bromosuccinate 
• 97-67-6 (S)-Malic acid 
• 636-61-3 D-Malic acid 
• 110-17-8 (2E)-but-2-enedioic acid 
• 16045-92-4 chlorosuccinic acid 
• 10035-10-6 hydrogen bromide 
• 20859-24-9 Dimethyl S-bromsuccinat 
• 904830-63-3 N-o-tolyl-L-aspartic acid 

Relevant articles and documents

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The total synthesis of 14-membered resorcylic acid lactone, Cochliomycin B has prescribed, in a convergent manner, from readily available starting materials, D-galactose, L-aspartic acid and ethyl acetoacetate. The key reactions involved in the synthesis are Julia-Kocienski olefination, E-selective Horner-Wadsworth-Emmons olefination and intramolecular lactonization.

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A stereoselective total synthesis of 16-membered C2-symmetric macrodiolide Pyrenophorol, Tetrahydropyrenophorol and 4,4-diacetylpyrenophorol have been accomplished. The synthesis started from commercially available L-Aspartic acid and the key reactions involved are regioselective epoxide opening, CBS reduction, Pinnick oxidation and Mitsunobu dilactonization.