397328-49-3

Basic information

• Product Name: 3-(4-CHLORO-2-AMINOPHENYL)ACRYLIC ACID ETHYL ESTER
• Synonyms: 3-(4-CHLORO-2-AMINOPHENYL)ACRYLIC ACID ETHYL ESTER;Ethyl 3-(2-aMino-4-chlorophenyl)acrylate
• CAS NO: 397328-49-3
• Molecular Formula: C11H12ClNO2
• Molecular Weight: 225.674
• Mol File: 397328-49-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 371.3°C at 760 mmHg
• Flash Point: 178.4°C
• Appearance: /
• Density: 1.245g/cm³
• Vapor Pressure: 1.04E-05mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: 2-8°C
• PKA: 0.66±0.10(Predicted)
• CAS DataBase Reference: 3-(4-CHLORO-2-AMINOPHENYL)ACRYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CHLORO-2-AMINOPHENYL)ACRYLIC ACID ETHYL ESTER(397328-49-3)
• EPA Substance Registry System: 3-(4-CHLORO-2-AMINOPHENYL)ACRYLIC ACID ETHYL ESTER(397328-49-3)

Safety Data

• Hazardous Substances Data: 397328-49-3(Hazardous Substances Data)

Usage

General Description

3-(4-Chloro-2-aminophenyl)acrylic acid ethyl ester is a chemical compound that is commonly used in the synthesis of pharmaceuticals and organic compounds. It is an ethyl ester derivative of 3-(4-Chloro-2-aminophenyl)acrylic acid, which is a carboxylic acid with an amino group and a chlorine substituent on the phenyl ring. 3-(4-CHLORO-2-AMINOPHENYL)ACRYLIC ACID ETHYL ESTER is often used as a building block in the synthesis of various drugs and organic compounds due to its versatile chemical structure and reactivity. It is important to handle and store this compound with care, as it is a potentially hazardous chemical that can cause harm if not handled properly.

InChI:InChI=1/C11H12ClNO2/c1-2-15-11(14)6-4-8-3-5-9(12)7-10(8)13/h3-7H,2,13H2,1H3/b6-4+

Upstream product

• 144-55-8 sodium hydrogencarbonate 
• 231294-99-8 ethyl 3-(4-chloro-2-nitrophenyl)acrylate 
• 41513-04-6 2-chloro-5-bromonitrobenzene 
• 140-88-5 ethyl acrylate 
• 6828-35-9 5-chloro-2-iodoaniline 

Relevant articles and documents

Recycled Pd/C-Catalyzed Heck Reaction of 2-Iodoanilines under Ligand-Free Conditions

Recyclable Pd/C-catalyzed Heck reaction of 2-iodoanilines with acrylate has been developed. The reaction occurred readily in 1,4-dioxane using Pd/C (10 wt%) as catalyst under ligand-free conditions, and the cross-coupling products were obtained with medium to high yield. Gram-scale reactions and recycling of the catalyst were also demonstrated.

ALPHA-CINNAMIDE COMPOUNDS AND COMPOSITIONS AS HDAC8 INHIBITORS

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2,3-substituted indole compounds as anti-inflammatory and analgesic agents

This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof wherein Z is OH, C1-6 alkoxy, —NR2R3 or heterocycle; Q is selected from the following: (a) an optionally substituted phenyl, (b) an optionally substituted 6-membered monocyclic aromatic group containing one, two, three or four nitrogen atom(s), (c) an optionally substituted 5-membered monocyclic aromatic group containing one heteroatom selected from O, S and N and optionally containing one, two or three nitrogen atom(s) in addition to said heteroatom, (d) an optionally substituted C3-7 cycloalkyl and (e) an optionally substituted benzo-fuzed heterocycle; R1 is hydrogen, C1-4 alkyl or halo; R2 and R3 are independently hydrogen, OH, C1-4 alkoxy, C1-4 alkyl or C1-4 alkyl substituted with halo, OH, C1-4 alkoxy or CN; X is independently selected from H, halo, C1-4 alkyl, halo-substituted C1-4 alkyl, OH, C1-4 alkoxy, halo-substituted C1-4 alkoxy, C1-4 alkylthio, NO2, NH2, di-(C1-4 alkyl)amino and CN; and n is 0, 1, 2, 3 and 4.This invention also provides a pharmaceutical composition useful for the treatment of a medical condition in which prostaglandins are implicated as pathogens.