397329-54-3

Basic information

• Product Name: tert-butyl 5-chloro-2-iodobenzoate
• Synonyms: tert-butyl 5-chloro-2-iodobenzoate
• CAS NO: 397329-54-3
• Molecular Weight: 338.573
• Mol File: 397329-54-3.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl 5-chloro-2-iodobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 5-chloro-2-iodobenzoate(397329-54-3)
• EPA Substance Registry System: tert-butyl 5-chloro-2-iodobenzoate(397329-54-3)

Safety Data

• Hazardous Substances Data: 397329-54-3(Hazardous Substances Data)

Upstream product

• 13421-00-6 5-chloro-2-iodo-benzoic acid 
• 75-65-0 tert-butyl alcohol 
• 289039-82-3 methyl 5-chloro-2-iodo-benzoate 

Relevant articles and documents

Rapid synthesis of 3-amino isocoumarin derivatives from ynamides

A novel and efficient fast synthesis of 3-amino isocoumarins in good to excellent yields is reported. These interesting scaffolds can be obtained either in a single step from readily available ynamides or in a two-step sequence from the corresponding alkynyl bromide after C-N cross-coupling. This protocol, which only requires a Br?nsted or Lewis acid as a promoter, offers an alternative approach toward synthesizing 3-substituted isocoumarins under smooth and fast conditions.

FIBROSIS INHIBITOR

Medicament being useful as a fibrosis inhibitor for organs or tissues, which comprises a compound of the formula (I): wherein Ring Z is optionally substituted pyrrole ring, etc.; W2 is -CO-, -SO2-, optionally substituted C1-C4 alkylene, etc.; Ar2 is optionally substituted aryl, etc.; W1 and Ar1 mean the following (1) and (2):(1) W1 is optionally substituted C1-C4 alkylene, etc.; Ar1 is optionally substituted bicyclic heteroaryl having 1 to 4 nitrogen atoms as ring-forming atoms:(2) W1 is optionally substituted C2-C5 alkylene, optionally substituted C2-C5 alkenylene, etc.; and Ar1 is aryl or monocyclic heteroaryl, which is substituted by carboxyl, alkoxycarbonyl, etc. at the ortho- or meta-position thereof with respect to the binding position of W1, or a pharmaceutically acceptable salt thereof.

Pyrrole derivatives

Pyrrole derivatives represented by the following formula: wherein Ring Z is an optionally substituted pyrrole ring, etc.; W2 is —CO—, —SO2—, an optionally substituted C1-C4 alkylene, etc.; Ar2 is an optionally substituted aryl, etc.; W2 and Ar1 mean the following (1) and (2): (1) W1 is an optionally substituted C1-C4 alkylene, etc.; Ar1 is an optionally substituted bicyclic heteroaryl having 1 to 4 nitrogen atoms as ring-forming atoms: (2) W1 is an optionally substituted C2-C5 alkylene, an optionally substituted C2-C5 alkenylene, etc.; and Ar1 is an aryl or monocyclic heteroaryl, which are substituted by carboxyl, an alkoxycarbonyl, etc. at the ortho- or meta-position thereof with respect to the binding position of W1, or a pharmaceutically acceptable salt thereof These compounds are useful as medicaments such as a fibrosis inhibitor for organs or tissues.