289039-82-3

Basic information

• Product Name: METHYL 5-CHLORO-2-IODOBENZOATE
• Synonyms: METHYL 5-CHLORO-2-IODOBENZOATE;Benzoic acid, 5-chloro-2-iodo-, methyl ester;5-chloro-2-iodo-Benzoic acid Methyl ester
• CAS NO: 289039-82-3
• Molecular Formula: C₈H₆ClIO₂
• Molecular Weight: 296.49
• Product Categories: Acids & Esters;Chlorine Compounds;Iodine Compounds
• Mol File: 289039-82-3.mol

Chemical Properties

• Boiling Point: 295.649°C at 760 mmHg
• Flash Point: 132.604°C
• Appearance: /
• Density: 1.838g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL 5-CHLORO-2-IODOBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-CHLORO-2-IODOBENZOATE(289039-82-3)
• EPA Substance Registry System: METHYL 5-CHLORO-2-IODOBENZOATE(289039-82-3)

Safety Data

• Hazardous Substances Data: 289039-82-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 5-CHLORO-2-IODOBENZOATE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, METHYL 5-CHLORO-2-IODOBENZOATE is utilized as a precursor in the production of various agrochemicals, such as pesticides and herbicides. Its presence in these compounds can contribute to their effectiveness in controlling pests and weeds.
Used in Materials Science:
METHYL 5-CHLORO-2-IODOBENZOATE has potential applications in materials science, where it can be used to develop new materials with specific properties. Its unique structure and reactivity make it a valuable component in the creation of advanced materials for various applications.
Used in Biochemistry:
In the field of biochemistry, METHYL 5-CHLORO-2-IODOBENZOATE can be employed as a reagent or a building block in the synthesis of biologically active compounds. Its presence in these compounds can contribute to their biological activity and potential use in therapeutic applications.
Overall, METHYL 5-CHLORO-2-IODOBENZOATE is a versatile chemical compound with a wide range of applications across different industries, including pharmaceutical, agrochemical, materials science, and biochemistry. Its unique structure and reactivity make it an essential component in the development of new products and materials with specific properties and functions.

InChI:InChI=1/C8H6ClIO2/c1-12-8(11)6-4-5(9)2-3-7(6)10/h2-4H,1H3

Upstream product

• 5202-89-1 4-chlorobenzenesulfonyl chloride 
• 13421-00-6 5-chloro-2-iodo-benzoic acid 
• 67-56-1 methanol 
• 171256-81-8 5-chloro-2-iodobenzoyl chloride 
• 74-88-4 methyl iodide 

Downstream Products

• 942273-38-3 methyl 5-chloro-2-((trimethylsilyl)ethynyl)benzoate 
• 397329-59-8 methyl 5-chloro-2-(3-hydroxyprop-1-yn-1-yl)benzoate 
• 397328-99-3 methyl 5-chloro-2-{(1Z)-3-[3-(1,3-dioxolan-2-yl)thien-2-yl]prop-1-enyl}benzoate 
• 3159-04-4 2-chlorodibenzo-1,4-thiazepin-11(10H)-one 
• 1505453-59-7 2-((4S)-6-(4-chlorophenyl)-1-methyl-8-(1-methyl-1H-pyrazol-4-yl)-4H-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide 
• 1505453-81-5 C₂₆H₂₄ClN₅O₂ 
• 1380089-79-1 methyl 2-(5-((E)-(((S)-tert-butylsulfinyl)imino)methyl)-3-methylisoxazol-4-yl)-5-chlorobenzoate 
• 1417741-80-0 5-chloro-2-[(2-ethynyl-4,5-dimethoxyphenyl)ethynyl]benzoic acid 
• 1418035-96-7 C₂₀H₁₅ClO₄ 
• 397329-44-1 methyl 5-chloro-2-{(1E)-4-[2-(4-methoxybenzoyl)-4-methyl-1H-pyrrol-1-yl]-1-butenyl}benzoate 
• 397329-54-3 tert-butyl 5-chloro-2-iodobenzoate 
• 942273-39-4 C₂₄H₂₁Cl₂NO₄S 

Relevant articles and documents

In situ catalytic generation of allylcopper species for asymmetric allylation: Toward 1H-isochromene skeletons

Stay active: Allylcopper species can be generated in situ through catalytic intramolecular oxycupration of allenic alcohol. The allylcopper can react with various aldehydes and a ketone to give 1H-isochromene derivatives in an enantioselective manner (see scheme; HMPA=hexamethylphosphoramide, THF=tetrahydrofuran). The protocol is atom-economical, highly regioselective, stereoconvergent, and tolerant to free hydroxy groups. Copyright

Facile synthesis of phthalides from methyl ortho-iodobenzoates and ketones via an iodinemagnesium exchange reaction using a silylmethyl Grignard reagent

Phthalides have been easily prepared by the treatment of methyl o-iodobenzoates with a silylmethyl Grignard reagent in the presence of ketones. The electron-withdrawing ester moiety of methyl o-iodobenzoates and the low nucleophilicity of the silylmethyl Grignard reagent prompted a smooth iodinemagnesium exchange reaction, at room temperature, without affecting the ester moiety or resulting in an undesired reaction with electrophilic ketones. This simple method, wherein special control of the reaction temperature was unnecessary, has allowed the synthesis of various phthalides, including a phenolphthalein derivative.

ISOCHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS

Compounds of formula (I) described herein are useful for inhibiting phosphoinositide 3-kinases (PI3K) and the treatment of disorders associated with PI3K enzymes.

ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS

The invention relates to compounds inhibiting phosphoinositide 3-kinases (PI3K), to pharmaceutical compositions comprising them and therapeutic use thereofin the treatment of disorders associated with PI3K enzymes.

BENZO [C] ISOXAZOLOAZEPINE BROMODOMAIN INHIBITORS AND USES THEREOF

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BROMODOMAIN INHIBITORS AND USES THEREOF

The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.

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FIBROSIS INHIBITOR

Medicament being useful as a fibrosis inhibitor for organs or tissues, which comprises a compound of the formula (I): wherein Ring Z is optionally substituted pyrrole ring, etc.; W2 is -CO-, -SO2-, optionally substituted C1-C4 alkylene, etc.; Ar2 is optionally substituted aryl, etc.; W1 and Ar1 mean the following (1) and (2):(1) W1 is optionally substituted C1-C4 alkylene, etc.; Ar1 is optionally substituted bicyclic heteroaryl having 1 to 4 nitrogen atoms as ring-forming atoms:(2) W1 is optionally substituted C2-C5 alkylene, optionally substituted C2-C5 alkenylene, etc.; and Ar1 is aryl or monocyclic heteroaryl, which is substituted by carboxyl, alkoxycarbonyl, etc. at the ortho- or meta-position thereof with respect to the binding position of W1, or a pharmaceutically acceptable salt thereof.

Pyrrole derivatives

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