397329-87-2

Upstream product

• 2949-22-6 Glycine ethyl ester isocyanate 
• 302840-67-1 (2R)-2-amino-3-(4-bromophenyl)-N-(3,5-dichlorophenyl)-2-methyl-propionamide 
• 397329-86-1 (R){3-[2-(4-Bromophenyl)-1-(3,5-dichlorophenylcarbamoyl)-1-methyl-ethyl]-ureido}-acetic acid ethyl ester 

Downstream Products

• 321656-72-8 (R)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1-hydroimidazo[1,2-a]imidazol-2-one 
• 397329-89-4 phosphoric acid 5-(4-bromobenzyl)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazol-3-yl ester diethyl ester 
• 321656-73-9 (R)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1H-imidazo[1,2-α]imidazol-2-one 
• 397329-91-8 [4-(4-bromo-benzyl)-1-(3,5-dichloro-phenyl)-4-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-ylamino]-acetic acid 
• 397329-88-3 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1,6-dehydroimidazo[1,2-a]imidazole-2,5-dione 

Relevant academic research and scientific papers

Development of a scalable process for 1-(3,5-dichlorophenyl)-5-iodo-3- methyl-(4-methylbenzyl)-1H-imidazo[1,2-a]imidazol-2-one: A key intermediate for the synthesis of LFA-1 inhibitors

A safe, robust, chromatography-free and reproducible process for the multi-kilogram synthesis of vinyl iodide 2, a key intermediate for the synthesis of LFA-1 inhibitors, was developed and implemented at the pilot plant. Execution of the above process all

Regiocontrolled synthesis of highly-functionalized fused imidazoles: A novel synthesis of second generation LFA-1 inhibitors

A new and reliable route to a new class of LFA-1 inhibitors such as (2) has been developed. A key aspect of this route is the transformation of amino amide 5 into iodide 3 in four steps. Iodide 3 is a key advanced intermediate used in the synthesis of all