397329-89-4

Upstream product

• 814-49-3 diethyl chlorophosphate 
• 397329-88-3 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1,6-dehydroimidazo[1,2-a]imidazole-2,5-dione 
• 302840-67-1 (2R)-2-amino-3-(4-bromophenyl)-N-(3,5-dichlorophenyl)-2-methyl-propionamide 
• 341027-25-6 (2R,5R)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trichloroacetyl)-imidazolidin-4-one 
• 341027-26-7 (2R,5R)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trichloroacetyl)-imidazolidin-4-one 
• 397329-87-2 [4-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-4-methyl-5-oxoimidazolidin-2-ylideneamino]acetic acid ethyl ester 
• 397329-86-1 (R){3-[2-(4-Bromophenyl)-1-(3,5-dichlorophenylcarbamoyl)-1-methyl-ethyl]-ureido}-acetic acid ethyl ester 
• 835917-14-1 3-(4-bromo-phenyl)-N-(3,5-dichloro-phenyl)-2-methyl-2-(5-oxo-2-thioxo-imidazolidin-1-yl)-propionamide 
• 835917-10-7 {[2-(4-bromo-phenyl)-1-(3,5-dichloro-phenylcarbamoyl)-1-methyl-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 835917-12-9 2-(2-amino-acetylamino)-3-(4-bromo-phenyl)-N-(3,5-dichloro-phenyl)-2-methyl-propionamide 
• 589-15-1 1-bromomethyl-4-bromobenzene 

Downstream Products

• 321656-73-9 (R)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1H-imidazo[1,2-α]imidazol-2-one 
• 321656-72-8 (R)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1-hydroimidazo[1,2-a]imidazol-2-one 

Relevant academic research and scientific papers

A practical synthesis of LFA-1 inhibitors utilizing CuCl-promoted intramolecular cyclization of thiohydantoins

An efficient and chromatography-free approach for synthesis of a new class of LFA-1 inhibitors was developed. A copper(I) chloride-promoted intramolecular cyclization of thiohydantoins 7a-b serves as a key step to highly functionalized bicyclic guanidines

Development of a scalable process for 1-(3,5-dichlorophenyl)-5-iodo-3- methyl-(4-methylbenzyl)-1H-imidazo[1,2-a]imidazol-2-one: A key intermediate for the synthesis of LFA-1 inhibitors

A safe, robust, chromatography-free and reproducible process for the multi-kilogram synthesis of vinyl iodide 2, a key intermediate for the synthesis of LFA-1 inhibitors, was developed and implemented at the pilot plant. Execution of the above process all

Regiocontrolled synthesis of highly-functionalized fused imidazoles: A novel synthesis of second generation LFA-1 inhibitors

A new and reliable route to a new class of LFA-1 inhibitors such as (2) has been developed. A key aspect of this route is the transformation of amino amide 5 into iodide 3 in four steps. Iodide 3 is a key advanced intermediate used in the synthesis of all