39736-27-1

Upstream product

• 10191-61-4 potassium S-methyl N-cyanocarbamodithioate 
• 532-27-4 1-chloroacetophenone 
• 70-11-1 α-bromoacetophenone 
• 412308-78-2 C₁₁H₁₀N₂OS₂ 
• 57626-33-2 2-bromo-1-phenyl-1,3-butanedione 
• 82060-31-9 C₃H₆N₄O₂S₂ 

Downstream Products

• 119038-87-8 7-Phenylthiazolo<4,5-d>pyrimidin-2-amin 
• 72100-53-9 4-amino-5-benzoyl-2-(4-morpholinyl)-1,3-thiazole 
• 1137537-03-1 N-[5-benzoyl-2-(methylthio)thiazole-4-yl]acetamide 
• 1202554-98-0 2-(methylthio)-9-phenyl-5,6,7,8-tetrahydrothiazolo[4,5-b]quinoline 
• 1443014-88-7 (4-chloro-2-(methylsulfanyl)-1,3-thiazol-5-yl)(phenyl)methanone 
• 1443014-89-8 (4-bromo-2-(methylsulfanyl)-1,3-thiazol-5-yl)(phenyl)methanone 
• 1202554-99-1 N-benzyl-9-phenyl-5,6,7,8-tetrahydrothiazolo[4,5-b]quinoline-2-amine 

Relevant academic research and scientific papers

NOVEL BRIDGED BICYCLOALKYL-SUBSTITUTED AMINOTHIZOLES AND THEIR METHODS OF USE

The present invention includes novel bridged bicycloalkyl-substituted aminothiazole compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject i

NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts

A NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts has been developed under mild conditions. This transformation involves sequential bromination/SN

4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K+-ATPase and Ras oncogene activity in cancer cells

The in vitro growth inhibitory activity of 26 thiazoles (including 4-halogeno-2,5-disubtituted-1,3-thiazoles) and 5 thienothiazoles was assessed on a panel of 6 human cancer cell lines, including glioma cell lines. (4-Chloro-2-(piperidin-1-yl)thiazol-5-yl)(phenyl)methanone (12a) and (4-bromo-2-(piperidin-1-yl)thiazol-5-yl)(phenyl)methanone (12b) displayed ～10 times greater in vitro growth inhibitory activity than perillyl alcohol (POH), which therapeutically benefits glioma patients through the inhibition of both alpha-1 Na+/K+-ATPase (NAK) and Ras oncogene activity. The in vitro cytostatic activities (as revealed by quantitative videomicroscopy) displayed by 12a and 12b were independent of the intrinsic resistance to pro-apoptotic stimuli associated with cancer cells. Compounds 12a and 12b displayed relatively similar inhibitory activities on purified guinea pig brain preparations that mainly express NAK alpha-2 and alpha-3 subunits, whereas only compound 12b was efficacious against purified guinea pig kidney preparations that mainly express the NAK alpha-1 subunit, which is also expressed in gliomas, melanomas and non-small-cell lung cancers NSCLCs.

NOVEL 2,4,5-TRISUBTITUTED-1,3-THIAZOLE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARATION, THERAPEUTIC AGENT FOR INFLAMMATORY DISEASE INDUCED BY SPC ACTIVITY CONTAINING 2,4,5- TRISUBSTITUTED-1,3-THIAZOLE DERIVATIVES AS AN EFF

Provided are a 2,4,5-trisubstiuted-l,3-thiazole derivative represented by the following Chemical Formula 1, a pharmaceutically acceptable salt thereof, a method for preparation thereof, and a use thereof as an effective ingredient in a therapeutic agent f

Heterocondensed thiophenes and thiazoles by Thorpe-Ziegler cyclization

(Chemical Equation Presented) The syntheses of novel thieno-pyridones, thiazolo-pyridones, thiazolo-pyridines and amino- and diamino-dieno-pyridines were described. Simultaneously, it was demonstrated that in these compounds and in the related 3-aminothio

A New Synthesis of Substituted 4-Amino-1,3-thiazoles

In the 5-position substituted 4-amino-2-alkylthio-1,3-thiazoles are prepared in good yields from N-nitro-amidino-dithiocarbamates 1 and α-halogen-carbonylcompounds or chloracetonitrile. 1 reacts with 1,3-dichlor-acetone under formation of adequate bis(1,3