3977-51-3

Basic information

• Product Name: 3-(o-Hydroxyphenyl)quinazolin-4(3H)-one
• Synonyms: 3-(o-Hydroxyphenyl)quinazolin-4(3H)-one
• CAS NO: 3977-51-3
• Molecular Formula: C₁₄H₁₀N₂O₂
• Molecular Weight: 238.24
• Mol File: 3977-51-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 429.6±47.0 °C(Predicted)
• Appearance: /
• Density: 1.30±0.1 g/cm3(Predicted)
• PKA: 9.32±0.35(Predicted)
• CAS DataBase Reference: 3-(o-Hydroxyphenyl)quinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(o-Hydroxyphenyl)quinazolin-4(3H)-one(3977-51-3)
• EPA Substance Registry System: 3-(o-Hydroxyphenyl)quinazolin-4(3H)-one(3977-51-3)

Safety Data

• Hazardous Substances Data: 3977-51-3(Hazardous Substances Data)

Upstream product

• 725-75-7 2-amino-N-(2-hydroxyphenyl)benzamide 
• 64-18-6 formic acid 
• 731-89-5 N-(2-hydroxyphenyl)-2-nitrobenzamide 

Relevant articles and documents

Furan-2-carbaldehydes as C1 building blocks for the synthesis of quinazolin-4(3: H)-ones via ligand-free photocatalytic C-C bond cleavage

Furan-2-carbaldehydes, as biomass-derived chemicals, are used as efficient green C1 building blocks to synthesize bioactive quinazolin-4(3H)-ones by ligand-free photocatalytic C-C bond cleavage. Notably, protection of hydroxyl, carboxyl, amide, or secondary amino groups is not required. Mechanistic studies suggest that conjugated N,O-tridentate copper complexes act as novel photoinitiators under visible light.

Diversified facile synthesis of benzimidazoles, quinazolin-4(3H)-ones and 1,4-benzodiazepine-2,5-diones via palladium-catalyzed transfer hydrogenation/condensation cascade of nitro arenes under microwave irradiation

A highly efficient diversified methodology for preparation of benzimidazole, quinazolin-4(3H)-ones and 1,4-benzodiazepine-2,5-diones is established using a palladium-catalyzed transfer hydrogenation (CTH)/condensation cascade of o-nitroaniline and o-nitrobenzamides in a triethylamine-formic acid azeotropic mixture (2:5) under microwave irradiation.