3977-51-3Relevant academic research and scientific papers
Furan-2-carbaldehydes as C1 building blocks for the synthesis of quinazolin-4(3: H)-ones via ligand-free photocatalytic C-C bond cleavage
Yu, Wenjia,Zhang, Xianwei,Qin, Bingjie,Wang, Qiyang,Ren, Xuhong,He, Xinhua
, p. 2449 - 2454 (2018/06/11)
Furan-2-carbaldehydes, as biomass-derived chemicals, are used as efficient green C1 building blocks to synthesize bioactive quinazolin-4(3H)-ones by ligand-free photocatalytic C-C bond cleavage. Notably, protection of hydroxyl, carboxyl, amide, or secondary amino groups is not required. Mechanistic studies suggest that conjugated N,O-tridentate copper complexes act as novel photoinitiators under visible light.
Synthetic method of nitrogenous heterocyclic compound
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Paragraph 0032; 0033; 0034, (2016/10/27)
The invention discloses a synthetic method of a nitrogenous heterocyclic compound, comprising: dissolving o-nitro aromatic hydrocarbon in triethylamine-methane acid mixture, adding Pd/c catalyst, irradiating with microwave at 130-180 DEG C for 5-10 min, and reacting to obtain a corresponding nitrogenous heterocyclic compound; the o-nitro aromatic hydrocarbon is o-nitro benzoyl amine or o-nitro aminobenzene.The o-nitro aromatic hydrocarbon is used as a starting material, the material is converted in the triethylamine-methane acid azeotropic mixture under microwave irradiation into a product by means of palladium catalytic transfer hydrogenation reduction and cyclic condensation, the method is efficient, environment-friendly and applicable to diversified substrates, and no side reaction occurs during the generation of the product.The reaction product is extracted with an organic reagent to remove the catalyst in the reaction system, and the nitrogenous heterocyclic compound pure product is obtained by rotary evaporation; separation and purification by column chromatography is not required.
Diversified facile synthesis of benzimidazoles, quinazolin-4(3H)-ones and 1,4-benzodiazepine-2,5-diones via palladium-catalyzed transfer hydrogenation/condensation cascade of nitro arenes under microwave irradiation
Zhu, Kaicheng,Hao, Jian-Hong,Zhang, Cheng-Pan,Zhang, Jiajun,Feng, Yiqing,Qin, Hua-Li
, p. 11132 - 11135 (2015/03/05)
A highly efficient diversified methodology for preparation of benzimidazole, quinazolin-4(3H)-ones and 1,4-benzodiazepine-2,5-diones is established using a palladium-catalyzed transfer hydrogenation (CTH)/condensation cascade of o-nitroaniline and o-nitrobenzamides in a triethylamine-formic acid azeotropic mixture (2:5) under microwave irradiation.
