725-75-7Relevant academic research and scientific papers
On the purity of 2-[ortho-anilinyl]-1,3-benzoxazole derived from 2H-3,1-benzoxazine-2,4(1H)dione (isatoic anhydride) [1,2]
Button, Karen M.,Gossage, Robert A.,Jenkins, Hilary A.,Mahdi, Tayseer,Resanovic, Sanja
, p. 268 - 271 (2010)
(Chemical Equation Presented) The Lewis acid catalyzed synthesis and chromatographic purification of isatoic anhydride-derived 2-(2′-anilinyl)- 1,3-benzoxazole (2) can result in the co-isolation of 2 and a light pink colored impurity (a predictable intermediate in the formation of 2. Compound 3 crystallizes in an orthorhombic crystal system of space group P2 12121 with four molecules in the unit cell (α = β = γ = 90°; a = 6.715 (2) A, b = 12.100 (4) A, c = 13.321 (4) A; V = 1082.2 (6) A3). Pure 2 is characterized as a colorless, high-melting solid; unlike the dark colored oil that is isolated if 2 contains traces of 3.
Efficient one-pot tandem synthesis and cytotoxicity evaluation of 2,3-disubstituted quinazolin-4(3H)-one derivatives
Bui, Hue Thi Buu,Do, Kiep Minh,Nguyen, Huy Tran Duc,Mai, Hieu Van,Danh, Thanh La Duc,Tran, De Quang,Morita, Hiroyuki
supporting information, (2021/09/08)
Twenty 2,3-disubstituted quinazolin-4(3H)-one derivatives 1–20 were successfully synthesized in moderate to good yields (25–82%). Their syntheses were based on a one pot tandem ring opening procedure followed by iodine-catalyzed oxidative cyclization of isatoic anhydride with aldehydes, using water as the only solvent under both classical and microwave irradiation conditions. Cytotoxicity assays of the prepared compounds against three human cancer cell lines (HeLa, MCF-7, and A549) indicated that 2, 3, and 20 possessed moderate activities against MCF-7 cells (IC50 = 47.2 μM, 43.9 μM, and 44.9 μM, respectively). Good cytotoxic activities against A549 cells were observed for 3 and 8 with IC50 values of 30.7 μM and 29.8 μM, respectively, which were comparable to the positive control, 5-fluorouracil (5-FU, IC50 = 27.9 μM). Furthermore, compound 4 exhibited slightly stronger activity (IC50 = 23.6 μM) than the positive control 5-FU against the A549 cell line.
Quinazolinone derivatives and production method and application thereof
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Paragraph 0082, (2020/02/14)
The invention discloses quinazolinone derivatives and a production method and application thereof. The quinazolinone derivatives are synthesized by means of the simple and convenient method, the yields are high, the production cost is low, with a concentr
