39784-29-7

Usage

Uses

Used in Biochemistry:
1-(2-styrylphenyl)tetrazol-1-ium is used as a redox indicator for assessing cell viability and proliferation. Its application reason is that it changes color in response to metabolic activity, making it useful for a variety of cell-based assays.
Used in Photodynamic Therapy:
In the medical field, 1-(2-styrylphenyl)tetrazol-1-ium is used as a potential photosensitizer. The application reason is that, when activated by light, it produces reactive oxygen species to destroy cancer cells.

Upstream product

• 18039-42-4 5-phenyl-2H-1,2,3,4-tetrazole 
• 591-50-4 iodobenzene 
• 79866-76-5 5-phenyl-1-vinyl-5H-tetrazole 
• 17578-18-6 1-vinyltetrazole 
• 93764-48-8 1-(2-ethoxycarbonyl-2-iodo-1-phenylethyl)-5-phenyltetrazole 
• 93742-50-8 1-(2-ethoxycarbonyl-2-hydroxy-1-phenylethyl)-5-phenyltetrazole 
• 83576-19-6 1-(2-hydroxy-2-phenylethyl)-5-phenyltetrazole 
• 96-09-3 styrene oxide 

Downstream Products

• 670-83-7 NSC 167196 

Relevant academic research and scientific papers

Vinyltetrazoles: III. Metal-catalyzed arylation, a new method of vinyltetrazoles functionalization

New functionalization procedure was developed for C- and N-vinyltetrazoles based on Heck reaction. Applying this method diverse (E)-styryl- and (E)-distyryltetrazoles were obtained for the first time in 76-85% yields. C-Vinyltetrazoles are more reactive in Heck cross-coupling than N-vinyltetrazoles. The arylation of 1-vinyltetrazole along Heck reaction proceeds with a C-H-activation and leads to the formation of 5-phenyl-1-[2-(E)-phenylethenyl]tetrazole.

Synthesis of Imidazoles from Alkenes

Alkenes are converted into imidazoles through their epoxides by a sequence involving ring-opening with readily available 2-tributylstannyltetrazoles (8), dehydration of the resulting alcohols (9) using methyltriphenoxyphosphonium iodide in a improved procedure to give 1-alkenyltetrazoles (12), which give imidazoles (17) on photolysis.