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398-63-0 Usage

Description

6-FLUORO-2H-1,4-BENZOXAZIN-3(4H)-ONE is a chemical compound characterized by the presence of a halogen (fluorine) at the C-6 position. This feature endows the molecule with significant phytotoxic activity, making it a compound of interest in various applications.

Uses

Used in Agricultural Industry:
6-FLUORO-2H-1,4-BENZOXAZIN-3(4H)-ONE is used as a phytotoxic agent for controlling the growth of unwanted plants and weeds. Its ability to inhibit plant growth makes it a potential candidate for use in herbicides, helping to protect crops and improve agricultural yields.
Used in Pharmaceutical Industry:
6-FLUORO-2H-1,4-BENZOXAZIN-3(4H)-ONE is used as a starting material or intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and properties can be exploited to develop new drugs with potential applications in treating different diseases and medical conditions.
Used in Chemical Research:
6-FLUORO-2H-1,4-BENZOXAZIN-3(4H)-ONE serves as a valuable compound for research purposes in the field of organic chemistry. Its study can lead to a better understanding of the properties and reactivity of halogenated benzoxazinones, which may contribute to the development of new chemical processes and applications.

Check Digit Verification of cas no

The CAS Registry Mumber 398-63-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,9 and 8 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 398-63:
(5*3)+(4*9)+(3*8)+(2*6)+(1*3)=90
90 % 10 = 0
So 398-63-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H6FNO2/c9-5-1-2-7-6(3-5)10-8(11)4-12-7/h1-3H,4H2,(H,10,11)

398-63-0 Well-known Company Product Price

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  • Aldrich

  • (557412)  6-Fluoro-2H-1,4-benzoxazin-3(4H)-one  97%

  • 398-63-0

  • 557412-1G

  • 793.26CNY

  • Detail
  • Aldrich

  • (557412)  6-Fluoro-2H-1,4-benzoxazin-3(4H)-one  97%

  • 398-63-0

  • 557412-5G

  • 3,052.53CNY

  • Detail

398-63-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-fluoro-4H-1,4-benzoxazin-3-one

1.2 Other means of identification

Product number -
Other names 6-fluoro-2,4-dihydro-1,4-benzoxazin-3-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:398-63-0 SDS

398-63-0Relevant articles and documents

Synthesis, docking, 3-D-qsar, and biological assays of novel indole derivatives targeting serotonin transporter, dopamine D2 receptor, and mao-a enzyme: In the pursuit for potential multitarget directed ligands

Alarcón-Espósito, Jazmín,Araya-Maturana, Ramiro,Cabezas, David,Cerda-Cavieres, Christopher,Chung, Hery,Iturriaga-Vásquez, Patricio,Mella-Raipán, Jaime,Ojeda-Gómez, Claudia,Pessoa-Mahana, Carlos D.,Pessoa-Mahana, Hernán,Quiroz, Gabriel,Reyes-Parada, Miguel,Rodríguez-Lavado, Julio,Saitz, Claudio

, (2020/10/18)

A series of 27 compounds of general structure 2,3-dihydro-benzo[1,4]oxazin-4-yl)-2-{4-[3-(1H-3indolyl)-propyl]-1-piperazinyl}-ethanamides, Series I: 7(a-o) and (2-{4-[3-(1H-3-indolyl) -propyl]-1-piperazinyl}-acetylamine)-N-(2-morfolin-4-yl-ethyl)-fluorinated benzamides Series II: 13(a-l) were synthesized and evaluated as novel multitarget ligands towards dopamine D2 receptor, serotonin transporter (SERT), and monoamine oxidase-A (MAO-A) directed to the management of major depressive disorder (MDD). All the assayed compounds showed affinity for SERT in the nanomolar range, with five of them displaying Ki values from 5 to 10 nM. Compounds 7k, Ki = 5.63 ± 0.82 nM, and 13c, Ki = 6.85 ± 0.19 nM, showed the highest potencies. The affinities for D2 ranged from micro to nanomolar, while MAO-A inhibition was more discrete. Nevertheless, compounds 7m and 7n showed affinities for the D2 receptor in the nanomolar range (7n: Ki = 307 ± 6 nM and 7m: Ki = 593 ± 62 nM). Compound 7n was the only derivative displaying comparable affinities for SERT and D2 receptor (D2/SERT ratio = 3.6) and could be considered as a multitarget lead for further optimization. In addition, docking studies aimed to rationalize the molecular interactions and binding modes of the designed compounds in the most relevant protein targets were carried out. Furthermore, in order to obtain information on the structure-activity relationship of the synthesized series, a 3-D-QSAR CoMFA and CoMSIA study was conducted and validated internally and externally (q2 = 0.625, 0.523 for CoMFA and CoMSIA and r2ncv = 0.967, 0.959 for CoMFA and CoMSIA, respectively).

New Approach to 1,4-Benzoxazin-3-ones by Electrochemical C?H Amination

Wesenberg, Lars Julian,Herold, Sebastian,Shimizu, Akihiro,Yoshida, Jun-Ichi,Waldvogel, Siegfried R.

supporting information, p. 12096 - 12099 (2017/09/13)

1,4-Benzoxazin-3-ones are important structural motifs in natural products and bioactive compounds. Usually, the synthesis of benzoxazinones requires transition-metal catalysts and pre-functionalized substrates such as aryl halides. However, the anodic C?H

TRICYCLIC SULFONAMIDE DERIVATIVES

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Paragraph 1277-1279, (2015/07/15)

The invention relates to derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of pain.

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