398-92-5Relevant academic research and scientific papers
A kind of benzo heterocyclic compound and its use for the treatment of cancer (by machine translation)
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Paragraph 0060; 0061; 0062; 0063, (2019/01/14)
The invention of the formula I indicated by the benzo heterocyclic compound, or its pharmaceutically acceptable salt, or its crystalline form, or solvate thereof, or its isotope body, or a tautomer thereof, or stereochemical isomers thereof. The experimen
Solvent-free aromatic C-H functionalisation/halogenation reactions
Bedford, Robin B.,Engelhart, Jens U.,Haddow, Mairi F.,Mitchell, Charlotte J.,Webster, Ruth L.
supporting information; experimental part, p. 10464 - 10472 (2011/01/05)
The solvent-free, palladium-catalysed reaction of anilides with CuCl 2 in the presence or absence of copper acetate yields ortho-chlorinated anilides in good to excellent yields, even on a large scale (100 mmol). By contrast, the equivalent reactions with copper bromide, either solvent free or in 1,2-dichloroethane, in the presence or absence of palladium, under air or inert conditions, gave the products of simple electrophilic bromination. Mechanistic studies highlighted the involvement of palladacyclic intermediates, one of which was characterised crystallographically, which undergo subsequent reaction with copper(ii) chloride to yield the chlorinated anilide products.
