39830-70-1Relevant articles and documents
Photoregulation of Gene Expression with Amantadine-Modified Caged siRNAs through Host–Guest Interactions
Zhang, Jinhao,Jing, Nannan,Fan, Xinli,Tang, Xinjing
, p. 14002 - 14010 (2020/10/02)
RNA interference is an essential and powerful tool for targeting and verifying specific gene functions. Conditional control of small interfering RNA (siRNA) activity, especially using light activation, is a potential method for regulating target gene expr
Photochemical regulation of gene expression using caged siRNAs with single terminal Vitamin E modification
Ji, Yuzhuo,Yang, Jiali,Wu, Li,Yu, Lijia,Tang, Xinjing
, p. 2152 - 2156 (2016/02/18)
Caged siRNAs with a single photolabile linker and/or vitamin E (vitE) modification at the 5′ terminal were rationally designed and synthesized. These virtually inactive caged siRNAs were successfully used to photoregulate both firefly luciferase and GFP g
Enantioconvergent hydrolysis of styrene epoxides by newly discovered epoxide hydrolases in mung bean
Xu, Wei,Xu, Jian-He,Pan, Jiang,Gu, Qing,Wu, Xin-Yan
, p. 1737 - 1740 (2007/10/03)
Two novel epoxide hydrolases were discovered in mung bean (Phaseolus radiatus L.) for the first time, either of which can catalyze enantioconvergent hydrolysis of styrene epoxides. Their regioselectivity coefficients are more than 90% for the p-nitrostyrene oxide. Furthermore, the crude mung bean powder was also shown to be a cheap and practical biocatalyst, allowing a one-step asymmetric synthesis of chiral (R)-diols from racemic epoxides, in up to >99% ee and 68.7% overall yield (after recrystallization).