398469-77-7Relevant academic research and scientific papers
Glycodendriproteins: A Synthetic Glycoprotein Mimic Enzyme with Branched Sugar-Display Potently Inhibits Bacterial Aggregation
Rendle, Phillip M.,Seger, Andreas,Rodrigues, Joao,Oldham, Neil J.,Bott, Richard R.,Jones, J. Bryan,Cowan, Marjorie M.,Davis, Benjamin G.
, p. 4750 - 4751 (2004)
The continuing ability of bacteria to resist current antibiotic treatments highlights the need for alternative strategies for inhibiting their pathogenicity. Bacterial attachment is a major factor in infectivity and virulence. This key binding phase of ba
SYNTHESIS AND USE OF GLYCODENDRIMER REAGENTS
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Page/Page column 41; sheet 25, (2010/11/08)
The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine n a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also a method of producing the chemically modified mutant protein is provided. The present invention also relates to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins. The present invention also relates to synthetic methods for producing thio-glycoses, the thio-glycoses so produced, and to methods for producing glycodendrimer reagents.
