39847-97-7

Upstream product

• 113416-23-2 (Z)-4-(4-Bromo-phenyl)-4-oxo-2-phenylamino-but-2-enoic acid methyl ester 
• 553-90-2 Dimethyl oxalate 
• 99-90-1 para-bromoacetophenone 
• 67-56-1 methanol 
• 55991-70-3 5-(4-bromo-phenyl)-furan-2,3-dione 

Downstream Products

• 188935-73-1 4-(4-Bromo-phenyl)-2,4-dioxo-3-(phenyl-hydrazono)-butyric acid methyl ester 

Relevant academic research and scientific papers

INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE, METHODS OF MARKING AND USES THEREOF

The present invention provides aryl- or heteroaryl- diketo acid compounds effective to inhibit an activity of a Mycobacterial malate synthase enzyme or to inhibit a malate synthase activity in other bacteria having the enzyme. The compounds may be phenyl-

Synthesis and SAR of 4-aryl-2-hydroxy-4-oxobut-2-enoic acids and esters and 2-amino-4-aryl-4-oxobut-2-enoic acids and esters: Potent inhibitors of kynurenine-3-hydroxylase as potential neuroprotective agents

The synthesis and structure-activity relationship of a series of 4-aryl- 2-hydroxy-4-oxobut-2-enoic acids and esters and 2-amino-4-aryl-4-oxobut-2- enoic acids and esters as potent inhibitors of kynurenine-3-hydroxylase are described. These compounds are

Study of the Mechanisms of Reactions of 1,3-Dicarbonyl Compounds with Nucleophilic Reagents: X. Kinetics of the Hydrolysis of Methyl 4-Aryl-2-Arylamino-4-Oxobut-2-Enoates

The kinetics of hydrolysis of methyl 4-aryl-2-arylamino-4-oxobut-2-enoates in 50% aqueous dioxane in the presence of acetate and monochloroacetate buffer solutions was studied by spectrophotometry. An analysis of the dependence of the rate of hydrolysis on the concentrations and the composition of the components of the solutions and on the nature of the substituents in the substrate made it possible to propose a mechanism of general acid catalysis of the reaction.

Kinetics of opening of the ring of 5-aryl-2,3-dihydrofuran-2,3-diones under the influence of methanol

The kinetics of the opening of the ring of 5-aryl-2,3-dihydrofuran-2,3-diones under the influence of methanol, which leads to the formation of methyl esters of aroylpyruvic acids, were studied by PMR spectroscopy. A mechanism is proposed for the reaction.