6918-93-0Relevant academic research and scientific papers
Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors
Wall, Mark J.,Chen, Jinsheng,Meegalla, Sanath,Ballentine, Shelley K.,Wilson, Kenneth J.,DesJarlais, Renee L.,Schubert, Carsten,Chaikin, Margery A.,Crysler, Carl,Petrounia, Ioanna P.,Donatelli, Robert R.,Yurkow, Edward J.,Boczon, Lisa,Mazzulla, Marie,Player, Mark R.,Patch, Raymond J.,Manthey, Carl L.,Molloy, Christopher,Tomczuk, Bruce,Illig, Carl R.
, p. 2097 - 2102 (2008/12/21)
A series of 3,4,6-substituted 2-quinolones has been synthesized and evaluated as inhibitors of the kinase domain of macrophage colony-stimulating factor-1 receptor (FMS). The fully optimized compound, 4-(4-ethyl-phenyl)-3-(2-methyl-3H-imidazol-4-yl)-2-qui
QUINOLINONE DERIVATIVES AS INHIBITORS OF C-FMS KINASE
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Page/Page column 58-59, (2010/02/10)
The invention is directed to compounds of Formulae I and II: (I) (II) wherein R1, R2, R3, R5, R6, Y1, Y2, Y3, Y4 and X are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.
