39885-08-0

Basic information

• Product Name: (2-AMINO-6-CHLORO-PHENYL)-METHANOL
• Synonyms: (2-AMINO-6-CHLORO-PHENYL)-METHANOL;2-Amino-6-chlorobenzyl alcohol;2-Chloro-6-aminobenzyl alcohol;Benzenemethanol,2-amino-6-chloro-;2-Amino-6-chlorobenzenemethanol
• CAS NO: 39885-08-0
• Molecular Formula: C₇H₈ClNO
• Molecular Weight: 157.59752
• Mol File: 39885-08-0.mol

Chemical Properties

• Melting Point: 76-78℃
• Boiling Point: 324.2°C at 760 mmHg
• Flash Point: 149.8°C
• Appearance: /
• Density: 1.341g/cm³
• Vapor Pressure: 0.000102mmHg at 25°C
• Refractive Index: 1.63
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 13.84±0.10(Predicted)
• CAS DataBase Reference: (2-AMINO-6-CHLORO-PHENYL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (2-AMINO-6-CHLORO-PHENYL)-METHANOL(39885-08-0)
• EPA Substance Registry System: (2-AMINO-6-CHLORO-PHENYL)-METHANOL(39885-08-0)

Safety Data

• Hazardous Substances Data: 39885-08-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(2-AMINO-6-CHLORO-PHENYL)-METHANOL is used as an intermediate in the synthesis of pharmaceuticals for its potential applications in drug discovery and development. Its unique structure allows for the creation of new drug candidates that can target specific biological pathways or diseases.
Used in Agrochemical Industry:
In the agrochemical industry, (2-AMINO-6-CHLORO-PHENYL)-METHANOL serves as an intermediate in the synthesis of various agrochemicals, contributing to the development of new pesticides, herbicides, and other agricultural chemicals that can improve crop yields and protect against pests.
Used in Organic Chemistry:
(2-AMINO-6-CHLORO-PHENYL)-METHANOL is used as a building block in organic chemistry for the preparation of various derivatives. Its presence in the synthesis of complex molecules highlights its importance in the development of novel chemical compounds with potential applications in various fields.
Used in Chemical Research:
(2-AMINO-6-CHLORO-PHENYL)-METHANOL is utilized in chemical research for studying the properties and reactions of phenol derivatives. Its unique structure provides opportunities for exploring new synthetic routes and understanding the reactivity of functional groups in organic molecules.

InChI:InChI=1/C7H8ClNO/c8-6-2-1-3-7(9)5(6)4-10/h1-3,10H,4,9H2

Upstream product

• 2148-56-3 2-chloro-6-aminobenzoic acid 
• 1404491-67-3 2-(3,5-dimethylphenyl)-5-isobutylquinoline 
• 67-63-0 isopropyl alcohol 
• 123-54-6 acetylacetone 
• 6575-11-7 2-amino-6-chlorobenzonitrile 

Downstream Products

• 1027961-10-9 4-(3-chloro-2-hydroxymethyl-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester 
• 852571-93-8 [2-chloro-6-(isopropylamino)phenyl]methanol 
• 35490-90-5 2-amino-6-chlorobenzaldehyde 
• 748805-74-5 3-chloro-2-[5-(3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-[1,3,4]oxadiazol-2-ylmethoxymethyl]-phenylamine 
• 1347720-70-0 C₂₁H₂₄ClN₃O₅ 
• 1404491-67-3 2-(3,5-dimethylphenyl)-5-isobutylquinoline 
• 1404491-66-2 5-chloro-2-(3,5-dimethylphenyl)quinoline 
• 1404491-69-5 2-(3,5-dimethylphenyl)-5-neopentylquinoline 
• 1404491-70-8 2-(3,5-dimethylphenyl)-5-isopentylquinoline 
• 1404491-71-9 5-(cyclopent-1-en-1-yl)-2-(3,5-dimethylphenyl)quinoline 
• 1404491-72-0 5-cyclopentyl-2-(3,5-dimethylphenyl)quinoline 
• 1404491-74-2 2-(3,5-dimethylphenyl)-5-ethylquinoline-d5 
• 1404491-76-4 2-(3,5-dimethylphenyl)-5-isobutyllquinoline-d9 
• 1347721-11-2 C₂₃H₂₇ClN₄O₃ 

Relevant articles and documents

Construction of a benzo[b]azepine skeleton through decarboxylative ylide [6+1] annulations with modified vinyl benzoxazinanones

A Lewis acid-promoted [6+1] annulation between sulfur ylides and modified vinyl benzoxazinanones was described. In this reaction, the newly designed vinyl benzoxazinanones could serve as a novel six-atom synthon, and the key to success is the installation of an electron-withdrawing group on the alkene moiety of the benzoxazinanones. A broad range of substrates are compatible with this mild reaction system, thereby providing a facile and practical approach for constructing a benzo[b]azepine skeleton.

A [4+3] Cycloaddition Reaction of Aza-ortho-quinone Methides with C,N-Cyclic Azomethine Imines for Synthesis of 1,2,4-Triazepines

The base-induced formal [4+3] cycloaddition reaction of C,N-cyclic azomethine imines with aza-ortho-quinone methides, generated in situ, is reported. This protocol provided an efficient method for the synthesis of biologically important 1,2,4-triazepine derivatives, with a wide substrate scope and excellent functional-group tolerance, and it gives moderate to excellent yields under mild conditions. Several of the derivatives exhibited in vitro antitumor activities against the A2780 cell line in a screening of the cancer cell lines HCT-116, H2228, and A2780 by an MTT assay.

IMIDAZOPIPERAZINONE INHIBITORS OF TRANSCRIPTION ACTIVATING PROTEINS

The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of transcription activating proteins such as CBP and P300 for the treatment or prevention of diseases such as proliferative diseases, inflammatory disorders, autoimmune diseases, and fibrotic diseases.

Red phosphorescent compound and organic electroluminescent device using same

The invention discloses a red phosphorescent compound and an organic electroluminescent device using the same. In the organic electroluminescent device comprising an anode, a hole injection layer, a hole transport layer, a light emitting layer, an electron transport layer, an electron injection layer and a cathode which are sequentially deposited, a phosphorescent compound as shown in a followingformula I can be used as a dopant of the light emitting layer, wherein R1, R2, R3, R4, R5 and R6 are independently selected from one of H, C1-C6 alkyls and C5-C8 cycloalkyls. The red phosphorescent material is high in efficiency, high in color purity and narrow in spectral effect.

ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE ORGANOMETALLIC COMPOUND, AND DIAGNOSTIC COMPOSITION INCLUDING THE ORGANOMETALLIC COMPOUND

An organometallic compound represented by Formula 1, an organic light-emitting device including the organometallic compound, and a diagnostic composition including the organometallic compound. wherein, in Formula 1, R1 to R12 and R19 are the same as described in the specification.

Benzoazepine-Fused Isoindolines via Intramolecular (3 + 2)-Cycloadditions of Azomethine Ylides with Dinitroarenes

Aminobenzaldehydes bearing a pendant 3,5-dinitrophenyl group react thermally with N-substituted α-amino acids to form unprecedented benzoazepine-fused isoindolines. The reaction proceeds via a dearomatization/rearomatization sequence involving an intramolecular (3 + 2)-cycloaddition between the in situ formed azomethine ylide and the dinitroarene. Various glycine derivatives are tolerated as well as branched substrates based on cyclic, α-mono-, and α,α-disubstituted amino acids, giving single diastereomers in many cases. The method is scalable and gives products with a nitro group ready for further manipulation.

HETEROARYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSTION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH PI3 KINASES, CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a heteroaryl derivative or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition for preventing or treating diseases associated with PI3 kinases, containing the same as an active ingredient. The heteroaryl derivative according to the present invention has an excellent effect of selectively inhibiting PI3 kinases, thereby being useful in preventing or treating PI3 kinase diseases such as: cancers, autoimmune diseases, and respiratory diseases.

Cyclo-aryl iridium compound and organic electroluminescence device using the compound

The present invention discloses a cyclo-aryl iridium compound and a phosphorescent organic electroluminescence (organic EL) device using the cyclo-aryl iridium compound as a light-emitting dopant of the light-emitting layer. The organic EL device has good

PhI(OAc)2-mediated dearomative C-N coupling: Facile construction of the spiro[indoline-3,2′-pyrrolidine] skeleton

A facile construction of the spiro[indole-3,2′-pyrrolidine] skeleton, through diacetoxyiodobenzene (PIDA) mediated C-N bond-forming dearomatization of C3 sulfonamide linked indole derivatives, has been developed. A variety of spiro-indolepyrrolidines were

A [4 + 3] Annulation Reaction of aza- o-Quinone Methides with Arylcarbohydrazonoyl Chlorides for Synthesis of 2,3-Dihydro-1 H-benzo[ e][1,2,4]triazepines

An unprecedented [4 + 3] annulation reaction of aza-ortho-quinone methides with arylcarbohydrazonoyl chlorides has been achieved under mild conditions. The annulation underwent a sequential conjugate addition/intramolecular annulation/rearrangement, providing a useful method for the synthesis of biologically interesting 2,3-dihydro-1H-benzo[e][1,2,4]triazepine.