39887-80-4

Upstream product

• 7461-41-8 4-chloro-N-(1-methylethyl)benzamide 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 27895-56-3 N-(2-propyl)-4-chlorobenzylideneamine 
• 104-88-1 4-chlorobenzaldehyde 
• 56-33-7 1,1,3,3-tetramethyl-1,3-diphenyldisiloxane 
• 99231-44-4 Methyl 5-[(4-chlorophenyl)(isopropylimino)methyl]-1,4-dimethyl-1H-pyrrole-2-acetate Perchlorate 
• 1252580-92-9 allyl N-isopropyl-4-chlorobenzimidate 

Relevant academic research and scientific papers

Semi-catalytic reduction of secondary amides to imines and aldehydes

Secondary amides can be reduced by silane HSiMe2Ph into imines and aldehydes by a two-stage process involving prior conversion of amides into iminoyl chlorides followed by catalytic reduction mediated by the ruthenium complex [Cp(i-Pr3P)Ru(NCCH3)2]PF6 (1). Alkyl and aryl amides bearing halogen, ketone, and ester groups were converted with moderate to good yields under mild reaction conditions to the corresponding imines and aldehydes. This procedure does not work for substrates bearing the nitro-group and fails for heteroaromatic amides. In the case of cyano substituted amides, the cyano group is reduced to imine.

METHOD FOR THE CATALYTIC REDUCTION OF ACID CHLORIDES AND IMIDOYL CHLORIDES

The present application relates to methods for the catalytic reduction of acid chlorides and/or imidoyl chlorides. The methods comprise reacting the acid chloride or imidoyl chloride with a silane reducing agent in the presence of a catalyst such as [Cp(Pri3P)Ru(NCMe)2]+[PF6]?.

Synthesis of chlorinated bicyclic C-fused tetrahydrofuro[3,2- c ]azetidin-2-ones

Some bicyclic C-fused chlorinated tetrahydrofuro[3,2-c]azetidin-2-ones were prepared by a fairly general route involving Staudinger reaction of allylic/propargylic imidates with dichloroketene followed by highly diastereoselective CuCl/PMDETA-catalyzed 5-

Imidoyl substituted pyrroles

Novel compounds, which are aryl-pyrrolyl-imine derivatives of the Formula I STR1 and acid addition salts thereof are disclosed; which compounds may be prepared by the acid catalyzed condensation of an imidoyl chloride with a lower alkyl pyrrole-2-acetate; and which compounds are useful as intermediates to form by hydrolysis, the known useful ketone analogs which have anti-inflammatory and analgesic activity; and certain of which compounds have antisecretory, anti-irritable bowel, antidiarrheal and general behavior effect on the CNS properties.

The Reaction between Cyanide Ion and Nitrones; a Novel Imidazole Synthesis

By contrast with the CN-diphenylnitrones, cold aqueous ethanolic potassium cyanide converts N-methyl-C-phenylnitrone into 1-methyl-4,5-diphenylimidazole.The scope of this reaction has been investigated, and shown to proceed via intermediate cyano-imines, some of which have been synthesised by alternative routes.