7461-41-8

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-N-isopropylbenzamide serves as an intermediate in the production of pharmaceuticals, playing a crucial role in the synthesis of various medicinal compounds. Its unique properties allow it to be a key component in the development of new drugs, contributing to the advancement of healthcare solutions.
Used in Agricultural Chemicals:
In the agricultural sector, 4-Chloro-N-isopropylbenzamide is utilized as an intermediate for the manufacture of agricultural chemicals. Its involvement in the synthesis of these chemicals aids in the creation of products that support crop protection and enhancement of agricultural yields.
Used as a Raw Material for Organic Compounds:
Beyond its applications in pharmaceuticals and agriculture, 4-Chloro-N-isopropylbenzamide also functions as a raw material for the synthesis of other organic compounds. Its versatility in chemical reactions makes it an essential precursor for a wide range of organic syntheses, further expanding its utility across different industries.

InChI:InChI=1/C10H12ClNO/c1-7(2)12-10(13)8-3-5-9(11)6-4-8/h3-7H,1-2H3,(H,12,13)

Upstream product

• 75-31-0 isopropylamine 
• 74-11-3 para-chlorobenzoic acid 
• 19172-47-5 Lawessons reagent 
• 945550-68-5 N-isopropyl-4-chlorobenzohydroxamic acid 
• 3031-21-8 bis(O,O-diisopropoxyphosphinothioyl)disulfide 
• 1144028-98-7 N-isopropyl-4-chlorobenzohydroxamic acid sodium salt 
• 598-45-8 i-propyl isocyanide 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 106-47-8 4-chloro-aniline 
• 2700-30-3 N,N-diisorpopylformamide 
• 106-43-4 para-chlorotoluene 
• 64-18-6 formic acid 
• 637-87-6 1-Chloro-4-iodobenzene 
• 693-13-0 diisopropyl-carbodiimide 

Downstream Products

• 39887-80-4 4-chloro-N-isopropylbenzimidoyl chloride 
• 85046-79-3 C₁₂H₁₁ClN₂O₃ 
• 1433955-28-2 4-chloro-N-isopropyl-5,6,7,8-tetraphenyl-1-naphthamide 
• 3277-80-3 (4-chlorophenyl)(cyclohexyl)methanone 
• 18713-58-1 1-(4-chlorophenyl)-2-methylpropan-1-one 
• 56-33-7 1,1,3,3-tetramethyl-1,3-diphenyldisiloxane 
• 104-88-1 4-chlorobenzaldehyde 
• 27895-56-3 N-(2-propyl)-4-chlorobenzylideneamine 
• 7335-27-5 ethyl 4-chlorobenzoate 
• 1126-46-1 Methyl 4-chlorobenzoate 

Relevant academic research and scientific papers

CuO-decorated magnetite-reduced graphene oxide: a robust and promising heterogeneous catalyst for the oxidative amidation of methylarenes in waterviabenzylic sp3C-H activation

A magnetite-reduced graphene oxide-supported CuO nanocomposite (rGO/Fe3O4-CuO) was preparedviaa facile chemical method and characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), UV-vis spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), Brunauer-Emmett-Teller (BET) analysis, vibrating-sample magnetometry (VSM), and thermogravimetric (TG) analysis. The catalytic activity of the rGO/Fe3O4-CuO nanocomposite was probed in the direct oxidative amidation reaction of methylarenes with free amines. Various aromatic and aliphatic amides were prepared efficiently at room temperature from cheap raw chemicals usingtert-butyl hydroperoxide (TBHP) as a “green” oxidant and low-toxicity TBAI in water. This method combines the oxidation of methylarenes and amide bond formation into a single operation. Moreover, the synthesized nanocomposites can be separated from the reaction mixtures using an external magnet and reused in six consecutive runs without a noticeable decrease in the catalytic activity.

Chemoselective Synthesis of α-Amino-α-cyanophosphonates by Reductive Gem-Cyanation-Phosphonylation of Secondary Amides

A novel approach to α-amino-α-cyanophosphonates has been developed. The method features a Tf2O-mediated reductive geminal cyanation/phosphonylation of secondary amides. Mild reaction conditions, high bond-forming efficiency, inexpensive readily available starting materials, and good to excellent yields with wide functional group compatibility constitute the main advantages of this method. The protocol can be run on a gram scale.

Convenient metal-free direct oxidative amidation of aldehyde using dibromoisocyanuric acid under mild conditions

A facile method for the direct synthesis of amides from aldehydes is described. Amide bonds were synthesized by an oxidative amidation in the presence of dibromoisocyanuric acid (DBI). Treatment of aromatic and aliphatic aldehydes with dibromoisocyanuric acid generated acyl bromide intermediates, which were employed to react with a variety of secondary and primary amines to give amides. Through this reaction method, various amides were synthesized directly from aldehydes under mild conditions in high yields and short times. This facile and efficient procedure provides potential strategy for the direct synthesis of amides from aldehydes.

Synthesis of Amides and Phthalimides via a Palladium Catalyzed Aminocarbonylation of Aryl Halides with Formic Acid and Carbodiimides

A novel method for the preparation of amides and phthalimides has been developed. The process involves a palladium catalyzed aminocarbonylation of an aryl halide, using a carbodiimide and formic acid as the carbonyl source. Experimental data suggest that the mechanistic pathway for this process involves in-situ generation of carbon monoxide from the reaction of formic acid with a carbodiimide in the presence of a palladium catalyst. The method can be used to produce a variety of amides and N-substituted phthalimides efficiently.

The copper-catalyzed cross-coupling reactions of aryl diazonium salts and isocyanides

The copper-catalyzed cross-coupling reaction of aryl diazonium salts and isocyanides has been performed. This is a successful example of preparation of arylcarboxyamides with moderate to good yield under mild conditions.

Semi-catalytic reduction of secondary amides to imines and aldehydes

Secondary amides can be reduced by silane HSiMe2Ph into imines and aldehydes by a two-stage process involving prior conversion of amides into iminoyl chlorides followed by catalytic reduction mediated by the ruthenium complex [Cp(i-Pr3P)Ru(NCCH3)2]PF6 (1). Alkyl and aryl amides bearing halogen, ketone, and ester groups were converted with moderate to good yields under mild reaction conditions to the corresponding imines and aldehydes. This procedure does not work for substrates bearing the nitro-group and fails for heteroaromatic amides. In the case of cyano substituted amides, the cyano group is reduced to imine.

METHOD FOR THE CATALYTIC REDUCTION OF ACID CHLORIDES AND IMIDOYL CHLORIDES

The present application relates to methods for the catalytic reduction of acid chlorides and/or imidoyl chlorides. The methods comprise reacting the acid chloride or imidoyl chloride with a silane reducing agent in the presence of a catalyst such as [Cp(Pri3P)Ru(NCMe)2]+[PF6]?.

Syntheses of amides via iodine-catalyzed multiple sp3 C-H bonds oxidation of methylarenes and sequential coupling with N,N-dialkylformamides

The oxidative coupling of methylarenes and N,N-dialkylformamides was developed, and the appropriate reaction conditions were established. By using I2 as the catalyst, and tert-butyl hydroperoxide (TBHP) as the oxidant, the reaction provided N,N

A transition-metal-free synthesis of arylcarboxyamides from aryl diazonium salts and isocyanides

A transition-metal-free carboxyamidation process, using aryl diazonium tetrafluoroborates and isocyanides under mild conditions, has been developed. This novel conversion was initiated by a base and solvent induced aryl radical, followed by radical addition to isocyanide and single electron transfer (SET) oxidation, affording the corresponding arylcarboxyamide upon hydration of the nitrilium intermediate.

Tandem Rh(III)-catalyzed oxidative acylation of secondary benzamides with aldehydes and intramolecular cyclization: The direct synthesis of 3-hydroxyisoindolin-1-ones

The rhodium-catalyzed oxidative acylation between secondary benzamides and aryl aldehydes via sp2 C - H bond activation followed by an intramolecular cyclization is described. This method results in the direct and efficient synthesis of 3-hydro