39890-59-0Relevant academic research and scientific papers
Synthetic studies toward the partial ergot alkaloid LY228729, a potent 5HT(1A) receptor agonist
Carr,Creviston,Hutchison,Kennedy,Khau,Kress,Leanna,Marshall,Martinelli,Peterson,Varie,Wepsiec
, p. 8640 - 8653 (2007/10/03)
Synthetic studies on LY228729 (3) afforded two innovative approaches for the construction of this class of partial ergoline 5HT(1a) receptor agonists. The first synthesis is based upon a diastereoselective epoxidation of racemic olefin 5, followed by ring
Stereoselective Epoxidations and Electrophilic Additions to Partial Ergot Alkaloids and Conformationally-Fixed Styrenes. Experimental and Theoretical Modeling Evidence for the Importance of Torsional Steering as a Stereocontrol Element
Martinelli, Michael J.,Peterson, Barry C.,Khau, Vien V.,Hutchison, Darrell R.,Leanna, M. Robert,et al.
, p. 2204 - 2210 (2007/10/02)
Partial ergot alkaloid substrates and related conformationally-fixed styrenes undergo epoxidation, osmium tetraoxide dihydroxylation, and hydrobromination with a level of stereoselectivity which cannot be explained by steric control but is consistent with
4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
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, (2008/06/13)
4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]-indole, useful as prolactin inhibitor and in treatment of Parkinsonisn.
