132557-13-2

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 39890-59-0 Phenyl-(5aS,6aS,7aR)-5a,6,6a,7a-tetrahydro-5H-7-oxa-4-aza-cyclopropa[e]acenaphthylen-4-yl-methanone 
• 132557-12-1 [(2aR,4R,5R)-4-Hydroxy-5-((S)-1-phenyl-ethylamino)-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl]-phenyl-methanone 
• 132619-31-9 [(2aS,4S,5S)-4-Hydroxy-5-((S)-1-phenyl-ethylamino)-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl]-phenyl-methanone 
• 132557-18-7 [(2aR,4R,5R)-6-Bromo-4-hydroxy-5-((S)-1-phenyl-ethylamino)-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl]-phenyl-methanone 

Downstream Products

• 132619-29-5 (+)-1-Benzoyl-1,2,2a,3,4,5-hexahydrobenzindol-4-amine 
• 115994-31-5 LY 228729 
• 132557-14-3 ((2aR,4S)-4-Amino-6-bromo-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone 
• 132557-15-4 ((2aR,4S)-6-Bromo-4-dipropylamino-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone 
• 132557-16-5 (+)-(2aR,4S)-1-benzoyl-4-(dipropylamino)-1,2,2α,3,4,5-hexahydrobenz-[cd]-indole-6-carbonitrile 
• 136791-10-1 (2aR,4S)-1-Benzoyl-4-dipropylamino-1,2,2a,3,4,5-hexahydro-benzo[cd]indole-6-carboxylic acid amide 
• 136816-12-1 ((2aR,4S)-4-Amino-6-iodo-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone 
• 133256-91-4 (+) (2aR,4S)-1-benzoyl-6-iodo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole 
• 132619-30-8 (-)-1-Benzoyl-1,2,2a,3,4,5-hexahydrobenzindol-4-amine 

Relevant academic research and scientific papers

Synthetic studies toward the partial ergot alkaloid LY228729, a potent 5HT(1A) receptor agonist

Synthetic studies on LY228729 (3) afforded two innovative approaches for the construction of this class of partial ergoline 5HT(1a) receptor agonists. The first synthesis is based upon a diastereoselective epoxidation of racemic olefin 5, followed by ring

THE SYNTHESIS OF (+)- AND (-)-1-BENZOYL-1,2,2a,3,4,5-HEXAHYDROBENZINDOL-4-AMINE, and PREPARATION OF LY228729

Racemic epoxide 5 was reacted with S-Phenylethylamine to afford diastereomers 6 and 7, from which amino alcohol 6 could be isolated directly.Aziridine formation and tandem-hydrogenolysis provided optically pure primary amine 2 (31percent from racemic 4),