39893-80-6

Basic information

• Product Name: 4-(3,4-DICHLORO-PHENYL)-THIAZOL-2-YLAMINE
• Synonyms: 4-(3,4-DICHLOROPHENYL)-1,3-THIAZOL-2-AMINE;4-(3,4-DICHLORO-PHENYL)-THIAZOL-2-YLAMINE;AKOS BBS-00006596;AKOS B000487;ART-CHEM-BB B000487;IFLAB-BB F1386-0380;4-(3,4-dichlorophenyl)-thiazol-2-amine;Zinc00035892
• CAS NO: 39893-80-6
• Molecular Formula: C₉H₆Cl₂N₂S
• Molecular Weight: 245.13
• Mol File: 39893-80-6.mol
• Article Data: 17

Chemical Properties

• Melting Point: 161.0 to 165.0 °C
• Boiling Point: 420.7 °C at 760 mmHg
• Flash Point: 208.3 °C
• Appearance: /
• Density: 1.498 g/cm³
• Vapor Pressure: 2.75E-07mmHg at 25°C
• Refractive Index: 1.673
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 4-(3,4-DICHLORO-PHENYL)-THIAZOL-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3,4-DICHLORO-PHENYL)-THIAZOL-2-YLAMINE(39893-80-6)
• EPA Substance Registry System: 4-(3,4-DICHLORO-PHENYL)-THIAZOL-2-YLAMINE(39893-80-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 39893-80-6(Hazardous Substances Data)

Usage

General Description

4-(3,4-Dichloro-phenyl)-thiazol-2-ylamine is a chemical compound that belongs to the thiazole class of compounds. It is a thiazole derivative with a 4-(3,4-Dichloro-phenyl) substituent. Thiazoles are known for their potential biological activities and have been studied for their antimicrobial, anti-inflammatory, and anticancer properties. This specific compound may have applications in the development of pharmaceuticals or agrochemicals due to its structural features and potential biological activities. Further research and development may be needed to explore its full range of potential applications and biological effects.

InChI:InChI=1/C9H6Cl2N2S/c10-6-2-1-5(3-7(6)11)8-4-14-9(12)13-8/h1-4H,(H2,12,13)

Upstream product

• 2642-63-9 3',4'-dichloroacetophenone 
• 2632-10-2 2-bromo-1-(3,4-dichlorophenyl)ethanone 
• 17356-08-0 thiourea 

Downstream Products

• 372093-95-3 N-[4-(3,4-Dichlorophenyl)thiazol-2-yl]-(2-chloro-5-nitrophenyl)carboxamide 
• 1366099-15-1 C₁₆H₁₅Cl₃N₆S 
• 1335009-63-6 N-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]-2-(2-methyl-1,1-dioxido-3-oxo-2,3-dihydro[1,3]thiazolo[3,2-b][1,2,4,6]thiatriazin-7-yl)acetamide 
• 68301-55-3 4-amino-N-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-benzenesulfonamide 
• 560090-53-1 4-((4-(3,4-dichlorophenyl)thiazol-2-yl)amino)-4-oxobutanoic acid 
• 1398574-78-1 C₁₄H₁₂Cl₂N₂O₃S 

Relevant articles and documents

Solid state thiazole-based fluorophores: Promising materials for white organic light emitting devices

A facile and more efficient solvent-free mechanochemical synthetic route has been developed for the synthesis of a series of solid state white light emissive thiazole-based donor-acceptor (D-A) type fluorophores, 2-(3-pyridyl)/2-aminothiazoles from ω-bromomethylketones and pyridine-3-carbothioamide/thiourea in the presence of silica-supported HClO4 as a reusable solid Br?nsted acid catalyst at RT. The photophysical and electrochemical properties of these compounds have been derived. Most of the studied D-A type solid thiazole-based fluorophores emitted white light and it can be tuned from warm - ideal - cold white light by introduction of a variety of substituents at 4th position of 2-(3-pyridyl)/2-aminothiazoles. Further, HOMO and LUMO energy levels of the titled compounds are found to be in the range ?5.52 eV to ?5.72 eV and ?1.84 eV to ?2.45 eV, respectively. The lifetimes of these levels of thiazole-based fluorophores have been determined through luminescence decay curves and are found to be in the range of 7.7–11 μs. The photophysical and electrochemical properties of the synthesized thiazole-based fluorophores indicate that the compounds could be promising materials for white organic light emitting devices.

SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.