39900-95-3

Usage

Type

Tetracycline antibiotic

Function

Inhibits the growth and reproduction of bacteria, stopping the spread of infection

Effective against

A wide range of gram-positive and gram-negative bacteria, as well as other microorganisms

Uses

Treatment of respiratory infections, skin infections, urinary tract infections, and certain sexually transmitted diseases

Side effects

Nausea, vomiting, diarrhea, and allergic reactions in some individuals

Precautions

Should be taken as prescribed by a healthcare professional to minimize the risk of adverse effects.

InChI:InChI=1/C16H16N2O2/c1-18(2)13-9-7-12(8-10-13)11-17-15-6-4-3-5-14(15)16(19)20/h3-11H,1-2H3,(H,19,20)/b17-11+

Upstream product

• 118-92-3 anthranilic acid 
• 100-10-7 4-dimethylamino-benzaldehyde 

Downstream Products

• 77810-69-6 2-{[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-amino}-benzoyl chloride 
• 86705-50-2 2-(2-{[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-amino}-phenyl)-benzo[d][1,3]oxazin-4-one 
• 86705-56-8 2-(2-{[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-amino}-phenyl)-3-[1,3,4]thiadiazol-2-yl-3H-quinazolin-4-one 
• 86705-68-2 2-(2-{[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-amino}-phenyl)-3-(5-methyl-[1,3,4]thiadiazol-2-yl)-3H-quinazolin-4-one 
• 86705-73-9 2-(2-{[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-amino}-phenyl)-3-(5-ethyl-[1,3,4]thiadiazol-2-yl)-3H-quinazolin-4-one 
• 86705-80-8 2-(2-{[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-amino}-phenyl)-3-(5-propyl-[1,3,4]thiadiazol-2-yl)-3H-quinazolin-4-one 
• 119541-83-2 Cu(C₁₆H₁₅N₂O₂)ClH₂O 
• 87897-74-3 {(OOC(C₆H₄)NCH(C₆H₄)N(CH₃)2)2(H₂O)2UO₂} 
• 119541-84-3 {Cu(C₁₉H₁₉N₄O₂)Cl(H₂O)}*H₂O 
• 119541-88-7 {Cu(C₂₈H₂₃N₄O₂)Cl}*H₂O 
• 841261-16-3 C₂₂H₁₉BrN₄O₂ 
• 841261-11-8 C₂₂H₁₉N₅O₄ 

Relevant academic research and scientific papers

Synthesis, characterization and use of Schiff bases as fluorimetric analytical reagents (part II)

Many Schiff bases were prepared by condensation reaction of certain aromatic amines with aromatic aldehydes derivatives and then the fluorescence properties of these Schiff bases were examined in acidic and basic media. It is shown that these compounds can be used for fluorimetric monitoring of small pH changes.

An expeditious one-pot synthesis of substituted phenylazetidin-2-ones in the presence of zeolite

In this study, one-pot rapid and efficient series of phenylazetidin-2-ones were synthesized from N,N-dimethylaminobenzaldehyde, different substituted aromatic amines and phenylacetyl chloride in the presence of zeolite catalyst under microwave irradiation. We also reported schiff bases (1a-j) by classical and conventional microwave technique. The titled compounds are evaluated for their antimicrobial properties. The activities are due to Ci=O, Ci-N, linkages in 2-azetidinones. All the compounds have shown comparable antibacterial activities.

Synthesis and antibacterial activities of some schiff bases

Schiff bases p-hydroxybenzylidene-2-carboxyaniline, p-nitrobenzylidene-2- carboxyaniline, p-(N, N-dimethyl)aminobenzylidene-2-carboxyaniline, N-(4-hydroxybezylidene)-benzene-1,2-diamine, N-(4-nitrobezylidene)benzene-1,2- diamine,N-(4-(N, N-dimethylaminobezylidene)benzene-1,2-diamine, N-(4-(N,Ndimethylamino) benzylidene)naphthalen-1-amine,N-(4-nitrobenzylidene) naphthalen-1-amine,N-(4-chlorobenzylidene)naphthalen-1-amine,sodium-4-(4-(N, N-dimethyl amino)benzylideneamino)naphthalene-1-sulfonate,sodium -4-(4-nitrobenzylideneamino) naphthalene-1-sulfonate and sodium-4-(4- chlorobenzylideneamino) naphthalene-1-sulfonate obtained by condensation of aniline and naphthylamine derivatives with some aromatic aldehydes were characterized by physical and spectral methods. The biological activity of these products were as antibacterial agents against three species of human pathogenic bacteria such as Escherichia coli, Staphylococcus aureus and Klebsiella sp. Nearly 50% of these compounds showed reasonable activity against the bacterial species investigated and we found that the antibacterial activity is dependent on the molecular structure of the compounds.

Synthesis, characterization and biological activity of some novel formazan derivatives

1-Substituted phenyl-3-substituted phenyl-4-(o-carboxyphenyl) formazans [3a-s] were synthesized by treating azomethines (A1-5) with diazonium salts. Compounds (A1-5) were synthesized by condensing anthranilic acid with various substituted aromatic aldehydes. All the synthesized compounds were characterized by IR, 1H NMR, Mass and elemental analysis and then evaluated for analgesic, antiinflammatory, antibacterial and antifungal activities.

Synthesis of some newer derivatives of 2-amino benzoic acid as potent anti-inflammatory and analgesic agents

Diazotization of N-benzylidene anthranilic acids 1a-1n at pH 9 yielded N-[α-(phenylazo) benzylidene] anthranilic acids 2a-2n and at pH 3 yielded N-benzylidene-5-(phenylazo) anthranilic acids 3a-3n. When compounds 3a-3n were treated with thioglycolic/thiolactic acid in the presence of anhydrous ZnCl 2, 2-(4-oxo-2-phenylthiazolidin-3-yl)-5-(phenylazo) benzoic acids 4a-4n were afforded. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activities and were compared with standard drugs, aspirin and phenylbutazone. Out of the compounds studied, the most active compound 4n showed more potent activity than the standard drugs at all doses tested.

Synthesis of 2-(o-Arylideneaminophenyl)-3-(5-alkyl-1,3,4-thiadiazol-2-yl)quinazolin-4-ones as Potential Anthelmintic Agents

A series of 2-(o-arylideneaminophenyl)-3-(5-alkyl-1,3,4-thiadiazol-2-yl)quinazolin-4-ones (13-41) have been synthesised and screened for their cestodicidal activity against Hymenolepis nana infection in rats.Compound 19 has been found to be the most active member of the series showing 77.2percent clearance of infection at a dose of 250 mg/kg given for 3 days.

The Role of Carboxyl Group of Anthranilic Acid on the Spectral Properties of its Schiff Bases and Acidity Constants of these Bases

The role of the carboxyl group of anthranilic acid on the spectral properties of its Schiff bases with aromatic aldehydes is elucidated.Band assignment for the different absorption bands observed in the spectra of these Schiff bases is made in the light of solvent polarity, molecular structure and spectral shifts observed in buffer solutions of varying pH's.Furthermore the possible pK values of these Schiff bases were determined and discussed in terms of molecular structure.