39948-18-0

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Methoxy-O,α-dimethyl-L-tyrosine is used as a precursor in the production of levodopa, a drug for treating Parkinson's disease. It plays a crucial role in the synthesis process, contributing to the development of medications that address neurological disorders.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 3-Methoxy-O,α-dimethyl-L-tyrosine is utilized for its potential anti-inflammatory and antioxidant properties. Its ability to inhibit monoamine oxidase, an enzyme involved in neurotransmitter breakdown, makes it a subject of interest for research aimed at discovering new therapeutic agents and treatments.

Upstream product

• 16825-27-7 (S)-N-Acetyl-α-methyl-β-(3,4-dimethoxyphenyl)alanin 
• 99531-07-4 (R)-2-(3,4-Dimethoxy-benzyl)-2-methyl-malonic acid monomethyl ester 
• 5846-22-0 2-(3,4-Dimethoxy-benzyl)-2-methyl-malonic acid dimethyl ester 
• 10144-60-2 4-(3,4-dimethoxy-benzyl)-2,4-dimethyl-4H-oxazol-5-one 
• 13967-60-7 3,4-Dimethoxy-α-methyl-phenylalanin-ethylester 
• 21852-32-4 4-bromomethyl-1,2-dimethoxybenzene 

Downstream Products

• 5211-38-1 (S)-4-(3,4-dimethoxy-benzyl)-2,4-dimethyl-4H-oxazol-5-one 
• 96589-41-2 4-(3,4-dimethoxy-benzyl)-2-[2-(3,4-dimethoxy-phenyl)-1-methyl-1-(toluene-4-sulfonylamino)-ethyl]-4-methyl-4H-oxazol-5-one 
• 84570-50-3 2-<(3,4-Dimethoxyphenyl)methyl>-2-<(2-hydroxy-2-phenylethanoyl)amino>propansaeure 
• 132970-18-4 (2S)-2-[(tert-butoxycarbonyl)amino]-2-methyl-3-(3,4-dimethoxyphenyl)propanoic acid 
• 1428736-53-1 (2R,5S)-5-(3,4-dimethoxybenzyl)-2,5-dimethyl-2-(pyridine-2-yl)imidazolidine-4-one 
• 1428736-54-2 (2S,5S)-5-(3,4-dimethoxybenzyl)-2,5-dimethyl-2-(pyridine-2-yl)imidazolidine-4-one 
• 1428736-51-9 (2R,5S)-5-(3,4-dimethoxybenzyl)-5-methyl-2-(pyridine-2-yl)imidazolidine-4-one 
• 1428736-52-0 (2S,5S)-5-(3,4-dimethoxybenzyl)-5-methyl-2-(pyridine-2-yl)imidazolidine-4-one 
• 109522-07-8 (S)-2-amino-3-(3,4-dimethoxyphenyl)-2-methylpropionamide 
• 84570-52-5 (3S,6S)-3-<(3,4-Dimethoxyphenyl)methyl>-3-methyl-6-phenylmorpholin 
• 84570-53-6 (3S,6R)-3-<(3,4-Dimethoxyphenyl)methyl>-3-methyl-6-phenylmorpholin 
• 555-30-6 methyldopa 

Relevant academic research and scientific papers

Biocatalytic Resolution of Tertiary α-Substituted Carboxylic Acid Esters: Efficient Preparation of a Quaternary Asymmetric Carbon Center

A method for resolving a variety of tertiary α-substituted carboxylic acid esters employing a previously undescribed enzyme is reported.

ENZYME CATALYSED HYDROLYSIS OF DIALKYLATED PROPANEDIOIC ACID DIESTERS, SYNTHESIS OF OPTICALLY PURE (S)-α-METHYLPHENYLALANINE, (S)-α-METHYLTYROSINE AND (S)-α-METHYL-3,4-DIHYDROXYPHENYLALANINE

Pig liver esterase and α-chymotrypsin catalysed hydrolysis of the meso-diesters 1, 2 and 3 gave the corresponding monoesters which then could be transformed into enantiomerically pure (S)-α-methylphenylalanine, (S)-α-methyltyrosine and (S)-α-methyl-3,4-dihydroxyphenylalanine.