99531-07-4

Basic information

• Product Name: (R)-2-(3,4-Dimethoxy-benzyl)-2-methyl-malonic acid monomethyl ester
• Synonyms: (R)-2-(3,4-Dimethoxy-benzyl)-2-methyl-malonic acid monomethyl ester
• CAS NO: 99531-07-4
• Molecular Weight: 282.293
• Mol File: 99531-07-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-(3,4-Dimethoxy-benzyl)-2-methyl-malonic acid monomethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(3,4-Dimethoxy-benzyl)-2-methyl-malonic acid monomethyl ester(99531-07-4)
• EPA Substance Registry System: (R)-2-(3,4-Dimethoxy-benzyl)-2-methyl-malonic acid monomethyl ester(99531-07-4)

Safety Data

• Hazardous Substances Data: 99531-07-4(Hazardous Substances Data)

Upstream product

• 21852-32-4 4-bromomethyl-1,2-dimethoxybenzene 
• 5846-22-0 2-(3,4-Dimethoxy-benzyl)-2-methyl-malonic acid dimethyl ester 

Downstream Products

• 555-30-6 methyldopa 
• 39948-18-0 (S)-3-(3,4-dimethoxyphenyl)-2-methylalanine  

Relevant articles and documents

ENZYME CATALYSED HYDROLYSIS OF DIALKYLATED PROPANEDIOIC ACID DIESTERS, SYNTHESIS OF OPTICALLY PURE (S)-α-METHYLPHENYLALANINE, (S)-α-METHYLTYROSINE AND (S)-α-METHYL-3,4-DIHYDROXYPHENYLALANINE

Pig liver esterase and α-chymotrypsin catalysed hydrolysis of the meso-diesters 1, 2 and 3 gave the corresponding monoesters which then could be transformed into enantiomerically pure (S)-α-methylphenylalanine, (S)-α-methyltyrosine and (S)-α-methyl-3,4-dihydroxyphenylalanine.