39964-89-1

Upstream product

• 18111-18-7 5-(iodomethyl)-1,2,3-trimethoxybenzene 
• 58754-95-3 N-(2,2-dimethoxyethyl)-p-toluenesulfonamide 
• 21852-50-6 3,4,5-trimethoxybenzyl bromide 
• 54879-83-3 N-(2'',2''-dimethoxyethyl)-3',4',5'-trimethoxyphenylmethylamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 3840-31-1 (3,4,5-trimethoxyphenyl)methanol 
• 39964-85-7 2,2-dimethoxy-N-<(3',4',5'-trimethoxyphenyl)methylene>ethylamine 

Downstream Products

• 36982-71-5 5,6,7-trimethoxyisoquinoline 
• 338730-15-7 N-(2,2-dimethoxyethyl)-N-[(2-iodo-3,4,5-trimethoxyphenyl)methyl]-p-toluenesulfonamide 
• 148492-77-7 ethyl 2-benzoyl-1-cyano-5,6,7-trimethoxy-1,2-dihydroisoquinoline-8-carboxylate 
• 148492-78-8 ethyl 2-benzoyl-1-cyano-5,6,7-trimethoxy-1-methyl-1,2-dihydroisoquinoline-8-carboxylate 
• 148492-83-5 ethyl 2-benzoyl-1-cyano-8-ethoxycarbonyl-5,6,7-trimethoxy-1,2-dihydroisoquinoline-1-ethanoate 

Relevant academic research and scientific papers

Total synthesis of tropoloisoquinolines: Imerubrine, isoimerubrine, and grandirubrine

A unified, ready access to the tropoloisoquinoline alkaloids imerubrine (1), grandirubrine (2), and isoimerubrine (3) is delineated and features sequential application of the intramolecular Diels - Alder reaction of an acetylene-tethered oxazole and the [

Studies Directed Towards Total Syntheses of the Tropoloisoquinoline Alkaloids Grandirubrine and Imerubrine. I. Preparation of Two 4,5,6-Trimethoxycyclopentisoquinolin-7-ones and Their Response to Robinson Annulation Conditions

In connection with efforts to develop total syntheses of the tropoloisoquinoline alkaloids grandirubrine (1) and imerubrine (2), preparations of tricyclic ketone (8) and the related ethoxycarbonyl system (47) are described.Of the various approaches to (8)

A SIMPLIFIED ISOQUINOLINE SYNTHESIS

A simple variation of the Pomeranz-Fritsch cyclization provides a short, efficient route to isoquinolines.Treatment of benzylic halides or mesylates 1 with the sodium anion of N-tosyl aminoacetaldehyde dimethyl acetal (2) followed by acid-catalyzed cyclization provides an effective, two-step preparation of isoquinolines 4.