400-59-9

Basic information

• Product Name: N-Butyltrifluoroacetamide
• Synonyms: N-Butyltrifluoroacetamide
• CAS NO: 400-59-9
• Molecular Formula: C₆H₁₀F₃NO
• Molecular Weight: 169.1449
• Mol File: 400-59-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 178.9°Cat760mmHg
• Flash Point: 62°C
• Appearance: /
• Density: 1.128g/cm³
• Vapor Pressure: 0.966mmHg at 25°C
• Refractive Index: 1.37
• CAS DataBase Reference: N-Butyltrifluoroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Butyltrifluoroacetamide(400-59-9)
• EPA Substance Registry System: N-Butyltrifluoroacetamide(400-59-9)

Safety Data

• Hazardous Substances Data: 400-59-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H10F3NO/c1-2-3-4-10-5(11)6(7,8)9/h2-4H2,1H3,(H,10,11)

Upstream product

• 354-38-1 2,2,2-trifluoroacetamide 
• 109-73-9 N-butylamine 
• 1536-78-3 2-butyl trifluoroacetate 
• 2923-18-4 sodium 2,2,2-trifluoroacetate 
• 383-63-1 ethyl trifluoroacetate, 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 14227-95-3 3-oxo-3-pyrrolidin-1-yl-propionitrile 
• 5456-97-3 N-butyl-4-methylbenzamide 
• 592-82-5 butyl isothiocyanate 
• 313-32-6 N-trifluoroacetyl-di-n-butylamine 

Relevant articles and documents

Efficient method for selective introduction of substituents as C(5) of isoleucine and other α-amino acids

A useful process for the position-selective remote bromination of N-trifluoroacetyl-α-amino esters is illustrated for the isoleucine case. The 5-bromoisoleucine derivative shown above can be used for the synthesis of many modified amino acids, as described herein.

A CO2-Catalyzed Transamidation Reaction

Transamidation reactions are often mediated by reactive substrates in the presence of overstoichiometric activating reagents and/or transition metal catalysts. Here we report the use of CO2as a traceless catalyst: in the presence of catalytic amounts of CO2, transamidation reactions were accelerated with primary, secondary, and tertiary amide donors. Various amine nucleophiles including amino acid derivatives were tolerated, showcasing the utility of transamidation in peptide modification and polymer degradation (e.g., Nylon-6,6). In particular,N,O-dimethylhydroxyl amides (Weinreb amides) displayed a distinct reactivity in the CO2-catalyzed transamidation versus a N2atmosphere. Comparative Hammett studies and kinetic analysis were conducted to elucidate the catalytic activation mechanism of molecular CO2, which was supported by DFT calculations. We attributed the positive effect of CO2in the transamidation reaction to the stabilization of tetrahedral intermediates by covalent binding to the electrophilic CO2

A convenient synthesis of Trifluoroacetamides from sodium trifluoroacetate and amines

Trifluoroacetamides were prepared readily by reaction of sodium trifluoroacetate with triphenylphosphine di-iodide and amines consecutively under mild conditions with good yields.