40002-24-2

Upstream product

• 186581-53-3 diazomethane 
• 40002-23-1 cyclohexa-1,5-diene-1-carboxylic acid 
• 60581-96-6 (+/-)-cis-2-acetoxy-cyclohex-3-enecarboxylic acid methyl ester 
• 65-85-0 benzoic acid 
• 93-58-3 benzoic acid methyl ester 
• 67-56-1 methanol 
• 784213-45-2 Cyclohexa-1,5-dienecarbonyl chloride 

Downstream Products

• 92011-99-9 methyl N-benzoyl-3-aza-2-oxabicyclo<2.2.2>oct-5-ene-5-carboxylate 
• 92011-98-8 methyl N-benzoyl-3-aza-2-oxabicyclo<2.2.2>oct-5-ene-6-carboxylate 
• 92011-98-8 N-benzoyl 5-methoxycarbonyl-2-aza-oxabicyclo<2.2.2>oct-4-ene 
• 96166-05-1 2-(hydroxymethyl)-1,3-cyclohexadiene 
• 92011-93-3 2-<<(tert-butyldimethylsilyl)oxy>methyl>-1,3-cyclohexadiene 
• 92011-94-4 N-benzoyl-3-aza-<<(tert-butyldimethylsilyl)oxy>methyl>-2-oxabicyclo<2.2.2>oct-5-ene 
• 92011-95-5 N-benzoyl-3-aza-5-<<(tert-butyldimethylsilyl)oxy>methyl>-2-oxabicyclo<2.2.2>oct-5-ene 
• 92012-05-0 (1R,2S,7S,8S)-10-Benzoyl-9-oxa-10-aza-tricyclo[6.2.2.0^2,7]dodec-4-ene-7-carboxylic acid methyl ester 
• 92012-04-9 N-benzoyl-3-aza-2-oxabicyclo<2.2.2>oct-5-ene-6-carboxylate 
• 92012-03-8 N-benzoyl-3-aza-6-(hydroxymethyl)-2-oxabicyclo<2.2.2>oct-5-ene 

Relevant academic research and scientific papers

Fast & easy preparation of 3D scaffolds from methyl benzoate by a diversity oriented synthesis strategy based on Diels-Alder and ene-reactions

Thermic dimerization of methyl 1,3-cyclohexadiene 2-carboxylate gave original 3D-shape compounds by Diels-Alder cycloaddition and original [6 + 4]-ene reaction. Further selective modifications on an endo [4 + 2] cycloadduct via a diversity oriented synthesis (DOS) strategy quickly led to the preparation of a small library of original 3D scaffolds, providing access to a larger and unexplored chemical space for drug discovery processes.

Regioselectivity of the Intermolecular Diels-Alder Reaction of Acyl Nitroso Compounds (C-Nitrosocarbonyl Compounds) and Nitrosoformates (O-Nitrosocarbonyl Compounds). Preparation of Functionalized cis-Δ6-1-Octalones

A study of the regioselectivity of the intermolecular Diels-Alder reaction of (nitrosocarbonyl)benzene and methyl nitrosoformate with representative electron-rich and electron-deficient 2-substituted 1,3-cyclohexadienes is described.The observed results are consistent with the prediction that nitrosocarbonyl compounds behave as dependable electron-deficient 2? components in a normal (HOMOdiene controlled) Diels-Alder reaction with electron-rich 2-substituted dienes and additionally illustrate that they may serve as useful 2? components in regioselective Diels-Alder reactions with electron-deficient 2-substituted 1,3-cyclohexadienes.The latter results are consistent with either a normal (HOMOdiene controlled) or inverse electron demand (LUMOdiene controlled) Diels-Alder reaction.Utilization of the nitrosocarbonyl Diels-Alder adducts in a stereospecific preparation of functionalized, cis-Δ6-1-octalone is detailed.In contrast to predictions based on secondary orbital control (allylic axial heteroatom orbital control), cycloaddition of butadiene with the 5- and 6-substituted N-benzoyl 3-aza-2-oxobicyclooct-5-enes occurs on the face bearing the RCON-O bridge.