40016-69-1

Upstream product

• 75-44-5 phosgene 
• 768-52-5 N-Isopropylaniline 
• 62-53-3 aniline 
• 1124-52-3 N-(propan-2-ylidene)aniline 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 178621-03-9 1-(2-chloroethyl)-4-(N-isopropyl-N-phenyl carbamoyl)-5(4H)-tetrazolinone 
• 1312718-56-1 C₁₇H₂₄N₂O₂ 
• 1350912-14-9 5,5-dimethyl-3-phenylhex-1-yn-3-yl isopropylcarbamate 
• 1350911-32-8 1-(4-methoxyphenyl)vinyl isopropylphenylcarbamate 
• 1350911-25-9 1-phenylvinyl isopropylphenylcarbamate 
• 1350911-29-3 1-(4-chlorophenyl)vinyl isopropylphenylcarbamate 
• 1350911-12-4 vinyl isopropylphenylcarbamate 
• 1350912-22-9 1-(dimethyl(phenyl)silyl)hexyl isopropylphenylcarbamate 
• 1350911-58-8 1-(dimethyl(phenyl)silyl)vinyl isopropylphenylcarbamate 
• 1350911-56-6 (E)-4-phenylbuta-1,3-dien-2-yl isopropylphenylcarbamate 
• 1350911-54-4 4-phenylbut-1-en-3-yn-2-yl isopropylphenylcarbamate 
• 1350911-52-2 4-(trimethylsilyl)but-1-en-3-yn-2-yl isopropylphenylcarbamate 
• 1350911-51-1 4-(triisopropylsilyl)but-1-en-3-yn-2-yl isopropylphenylcarbamate 
• 1350911-41-9 5,5-dimethylhex-1-en-3-yn-2-yl isopropylphenylcarbamate 

Relevant academic research and scientific papers

Synthesis of β-Lactams by Palladium(0)-Catalyzed C(sp3)?H Carbamoylation

A general and user-friendly synthesis of β-lactams is reported that makes use of Pd0-catalyzed carbamoylation of C(sp3)?H bonds, and operates under stoichiometric carbon monoxide in a two-chamber reactor. This reaction is compatible with a range of primary, secondary and activated tertiary C?H bonds, in contrast to previous methods based on C(sp3)?H activation. In addition, the feasibility of an enantioselective version using a chiral phosphonite ligand is demonstrated. Finally, this method can be employed to synthesize valuable enantiopure free β-lactams and β-amino acids.

Tertiary alcohols by tandem β-carbolithiation and N→C aryl migration in enol carbamates

Enol carbamates (O-vinylcarbamates) derived from aromatic or α,β-unsaturated compounds and bearing an N-aryl substituent undergo carbolithiation by nucleophilic attack at the (nominally nucleophilic) β position of the enol double bond. The resulting carbamate-stabilized allylic, propargylic, or benzylic organolithium rearranges with N→C migration of the N-aryl substituent, creating a quaternary carbon α to O. The products may be readily hydrolyzed to yield multiply branched tertiary alcohols in a one-pot tandem reaction, effectively a polarity-reversed nucleophilic β-alkylation-electrophilic α-arylation of an enol equivalent.

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists

Novel quaternary ammonium derivatives of N,N-disubstituted (3R)-quinuclidinyl carbamates have been identified as potent M3 muscarinic antagonists with long duration of action in an in vivo model of bronchoconstriction. These compounds have also presented a high level of metabolic transformation (human liver microsomes). The synthesis, structure-activity relationships and biological evaluation of these compounds are reported.

Process for the preparation of 1-4-disubstituted-5 (4H)-tetrazolinones

1,4-Disubstituted-5(4H)-tetrazolinones of the formula (I) STR1 wherein R1, R2 and R3 have the meanings given in the specification), which are known to be useful as herbicides, can be obtained in very good yields by reacting the corresponding 1-substituted-5(4H)-tetrazolinones with the corresponding carbamoyl chlorides in the presence of 4-dimethylaminopyridine.