40018-40-4

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 77925-51-0 2-(N,N-diethylaminosulfonyl)nitrobenzene 
• 3306-62-5 2-AMINOBENZENESULFONAMIDE 
• 74-11-3 para-chlorobenzoic acid 
• 106-43-4 para-chlorotoluene 
• 622-95-7 4-chlorobenzyl bromide 
• 23822-87-9 2-(4-chlorobenzylamino)benzenesulfonamide 
• 873-76-7 para-Chlorobenzyl alcohol 

Relevant academic research and scientific papers

Metal-free sequential dual oxidative amination of C(sp3)–H bonds: A direct approach to benzothiadiazine 1,1-dioxide derivatives

An efficient and metal-free Di-tert-butyl peroxide (DTBP)-promoted dual oxidative amination annulation of 2-amino arylsulfonamide with methylarene has been developed. This protocol provides straightforward access to benzothiadiazine 1,1-dioxide derivatives without using prefunctionalized substrates in good to excellent yields with good functional group tolerance.

Sulfate Radical Anion (SO4?-) Mediated C(sp3)-H Nitrogenation/Oxygenation in N-Aryl Benzylic Amines Expanded the Scope for the Synthesis of Benzamidine/Oxazine Heterocycles

A transition-metal-free, K2S2O8-mediated intramolecular oxidative nitrogenation/oxygenation of C(sp3)-H in N-aryl benzylic amines followed by oxidation at the benzylic center has been developed for the synthesis of benzamidine/benzoxazine heterocycles, providing an expedient access to quinazolin-4(3H)-ones, N-aryl-2-arylbenzimidazoles, and 4H-3,1-benzoxazin-4-ones. A considerable amount of work dealing with the mechanistic study to understand the crucial intramolecular cyclization step largely favors an iminium ion as the key intermediate.

Oxidative synthesis of quinazolinones and benzothiadiazine 1,1-dioxides from 2-aminobenzamide and 2-aminobenzenesulfonamide with benzyl alcohols and aldehydes

An interesting procedure for the zinc-catalyzed oxidative transformation of ready available 2-aminobenzamide, 2-aminobenzenesulfonamide with benzyl alcohols has been developed. Various quinazolinones and benzothiadiazine 1,1-dioxides were prepared in moderate to good yields under identical conditions. The reactions of both aromatic aldehydes and aliphatic aldehydes with 2-aminobenzamide under catalyst free conditions were described as well. In water media, the products were formed in good yields.

Facile synthesis of 2H-1,2,4-benzothiadiazine 1,1-dioxides promoted by Sml2

2H-1,2,4-Benzothiadiazine 1,1-dioxides are prepared in good yields via reductive cyclisation of N,N-diethyl-o-nitrobenzenesulfonamides with appropriate nitriles promoted by Sml2 under mild and neutral conditions.