40033-95-2

Upstream product

• 2524-64-3 chlorophosphoric acid diphenyl ester 
• 161659-96-7 3-<(2R)-2-<(3S,4R)-1-<(allyloxycarbonyl)methyl>-3-<(1R)-1-(tert-butyldimethylsilyloxy)ethyl>-2-oxoazetidin-4-yl>propionyl>spiro<2H-1,3-benzoxazine-2,1'-cyclohexan>-4(3H)-one 
• 67-56-1 methanol 
• 106-47-8 4-chloro-aniline 
• 619-66-9 4-Carboxybenzaldehyde 
• 158299-05-9 3-(2-Bromopropionyl)spiro-<2,3-dihydro-4H-1,3-benzoxazine-2,1'-cyclohexan>-4-one 
• 104-94-9 4-methoxy-aniline 
• 371-40-4 4-fluoroaniline 
• 95-53-4 o-toluidine 
• 62-53-3 aniline 
• 95-64-7 4-amino-o-xylene 
• 106-49-0 p-toluidine 
• 158299-15-1 3-<(2R)-2-<(2R,3S)-3-<(1R)-1-(tert-Butyldimethylsiloxy)ethyl>-4-oxoazetidin-2-yl>propionyl>spiro-<2,3-dihydro-4H-1,3-benzoxazine-2,1'-cyclohexan>-4-one 

Downstream Products

• 158299-05-9 3-(2-Bromopropionyl)spiro-<2,3-dihydro-4H-1,3-benzoxazine-2,1'-cyclohexan>-4-one 
• 126492-13-5 C₂₁H₂₁NO₃ 
• 126492-15-7 C₂₁H₁₉Cl₂NO₃ 
• 126492-08-8 C₂₂H₂₃NO₃S 
• 126492-10-2 C₂₂H₂₁Cl₂NO₃S 
• 1332594-11-2 3-(2-chloro-1-oxopropyl)spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one 
• 162924-34-7 3-(1-oxopropyl)spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one 

Relevant academic research and scientific papers

Soluble polymer-supported synthesis of trans β-lactams with high diastereoselectivity

A general method for the liquid-phase synthesis of trans β-lactams with high diastereoselectivity is described. The mechanism can be explained by a chair-like transition state involving the imine and the (Z)-enolate.

2-Substituted 2,3-dihydro-4H-1,3-benzoxazin-4-ones: Novel auxiliaries for stereoselective synthesis of 1-β-methylcarbapenems

The dihydrobenzoxazone 9e, which is easily prepared from salicylamide 11 and cyclohexanone, serves as an efficient auxiliary in the synthesis of the 1-β-methylcarbapenem key intermediate 10. The stereocontrolled Reformatsky-type reactions of the acetoxyazetidinone 2 with the carboximides 6 gave the intermediates 7 with high diastereoselectivities in high chemical yields. The auxiliary 9e also acts as a good leaving guoup in the TMSCl-promoted Dieckmann-type cyclization leading to a 1-β-methylcarbapenem skeleton. By using this auxiliary, 10 was synthesized in 58% overall yield and four steps from 2.