40058-88-6

Basic information

• Product Name: TERT-BUTYL-2-CHLOROPROPIONATE
• Synonyms: TERT-BUTYL-2-CHLOROPROPIONATE
• CAS NO: 40058-88-6
• Molecular Formula: C₇H₁₃ClO₂
• Molecular Weight: 164.62992
• Mol File: 40058-88-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 158.4°C at 760 mmHg
• Flash Point: 40.1°C
• Appearance: /
• Density: 1.032g/cm³
• Vapor Pressure: 2.63mmHg at 25°C
• Refractive Index: 1.428
• CAS DataBase Reference: TERT-BUTYL-2-CHLOROPROPIONATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL-2-CHLOROPROPIONATE(40058-88-6)
• EPA Substance Registry System: TERT-BUTYL-2-CHLOROPROPIONATE(40058-88-6)

Safety Data

• Hazardous Substances Data: 40058-88-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H13ClO2/c1-5(8)6(9)10-7(2,3)4/h5H,1-4H3

Upstream product

• 115-11-7 isobutene 
• 598-78-7 (R,S)-2-chloropropionic acid 
• 109-69-3 n-Butyl chloride 
• 111757-80-3 (-)-(2S)-trifluoromethanesulfonyloxy-propionic acid tert-butyl ester 
• 7623-09-8 2-chloropropionyl chloride 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 59415-37-1 (S)-tert-butyl 2-phenylpropionate 
• 66937-63-1 N-benzylalanine tert-butyl ester 
• 141540-17-2 (-)-t-butyl trans-2,3-bis(diphenylphosphinyl)-1-methyl-1-cyclopropanecarboxylate 
• 141540-17-2 (+)-t-butyl trans-2,3-bis(diphenylphosphinyl)-1-methyl-1-cyclopropanecarboxylate 
• 141540-18-3 (2S,3S)-2,3-Bis-diphenylphosphanyl-1-methyl-cyclopropanecarboxylic acid tert-butyl ester 
• 141540-18-3 (2S,3S)-2,3-Bis-diphenylphosphanyl-1-methyl-cyclopropanecarboxylic acid tert-butyl ester 
• 88430-80-2 tert-butyl 2-(3-fluoro-4-nitrophenyl)propionate 
• 141540-17-2 (+/-)-tert-butyl trans-2,3-bis(diphenylphosphinyl)-1-methyl-1-cyclopropanecarboxylate 

Relevant articles and documents

A trilactone related to anemonin

Treatment of anemonin sequentially with two equivalents of the anion 2 and iodine gave the monoalkylated monoiodinated iodolactone t-butyl ester 3. Ester cleavage in anhydrous acidic media followed by treatment with sodium hydrogen carbonate transformed 3 to trilactone 4.

Zinc-catalyzed enantiospecific sp3-sp3 cross-coupling of α-hydroxy ester triflates with grignard reagents

(Chemical Equation Presented) Zinc chloride does the trick and efficiently catalyzes the enantiospecific cross-coupling of α-hydroxy ester triflates with Grignard reagents under mild conditions. Enantiopure α-hydroxy esters are directly available from the chiral pool or by diazotization of α-amino acids. Substantial variations in both reacting partners are tolerated making this methodology an attractive alternative to enolate alkylation featuring a reversal of polarity.