400652-57-5

Usage

Uses

Used in Pharmaceutical Industry:
(R)-(2-AMINO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER is used as a chiral building block for the synthesis of various pharmaceutical compounds. It plays a crucial role in the development of new drugs, contributing to the creation of enantiomerically pure compounds, which are essential for ensuring the desired therapeutic effects and minimizing potential side effects.
Used in Organic Synthesis:
In the realm of organic synthesis, (R)-(2-AMINO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER serves as a reagent, facilitating the formation of complex organic molecules. Its unique structure allows for specific reactions that can lead to the production of a wide range of chemical entities, expanding the scope of synthetic chemistry.
Used in Preparation of Pharmaceutical Intermediates:
As a precursor in the preparation of pharmaceutical intermediates, (R)-(2-AMINO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER is instrumental in the production of key compounds that are further processed or modified to yield the final drug substances. Its presence in this stage of the pharmaceutical manufacturing process highlights its importance in the overall drug development pipeline.

Upstream product

• 1044851-42-4 1,1-dimethylethyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropyl]carbamate 
• 22820-51-5 1-amino-3-phenylpropan-2-ol hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 162541-45-9 (RS)-2-<(tert-Butoxycarbonyl)amino>-1-benzylethanol 
• 705-60-2 (2-nitroprop-1-enyl)benzene 
• 4436-24-2 1,2-epoxy-3-phenylpropane 
• 50411-26-2 3-phenyl-2-hydroxypropylamine 

Downstream Products

• 1430058-81-3 C₂₁H₂₄BrN₃O₃ 

Relevant academic research and scientific papers

A Novel Entry to 3,4,5-Trisubstituted 2-Pyrrolidones from Isoxazoline-N-oxides

A novel strategy for the synthesis of stereochemically defined 3,4,5-trisubstituted 2-pyrrolidones was developed. The suggested approach involves reductive domino-type recyclization of 3-aminomethyl-substituted isoxazolines as a key stage. The latter are prepared via α-C-H functionalization of readily available isoxazoline-N-oxides.

METHOD OF PRODUCING PYRONE AND PYRIDONE DERIVATIVES

The present invention provides a pyrone derivative and a pyridone derivative, which are novel intermediates for synthesizing an anti-influenza drug, a method of producing the same, and a method of using the same.

1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS

The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) wherein R1, R2, R3, and A are as described in the description and their use as medicaments, especially as orexin receptor antagonists.

1,2-DIAMIDO-ETHYLENE DERIVATIVES

The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) NHNR 3 OAOR 1 R 2 (I) wherein R1, R 2, R 3, and A are as described in the description and their use as medicaments, especially as orexin receptor

7-azaindol-3-ylacrylamides active as kinase inhibitors

Compounds represented by Formula (I) wherein R1 and R2 are as defined in the specification, compositions thereof, and methods of use thereof.

INHIBITORS OF AKT ACTIVITY

Invented are novel heterocyclic carboxamide compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

INHIBITORS OF AKT ACTIVITY

Invented are novel pyrazole compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

2-6-diaminopurine precursors

The present invention relates to compounds of formula (IV): STR1 wherein Ra and Rb each represent a hydrogen atom or together form an alkylidene group.