40070-06-2

Basic information

• Product Name: 4,6-diaminopyrimidine-2-sulfinic acid
• CAS NO: 40070-06-2
• Molecular Formula: C₄H₆N₄O₂S
• Molecular Weight: 174.181
• Mol File: 40070-06-2.mol

Chemical Properties

• Boiling Point: 719.2°C at 760 mmHg
• Flash Point: 388.8°C
• Density: 1.92g/cm³
• Vapor Pressure: 1.04E-21mmHg at 25°C
• Refractive Index: 1.835
• CAS DataBase Reference: 4,6-diaminopyrimidine-2-sulfinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-diaminopyrimidine-2-sulfinic acid(40070-06-2)
• EPA Substance Registry System: 4,6-diaminopyrimidine-2-sulfinic acid(40070-06-2)

Safety Data

• Hazardous Substances Data: 40070-06-2(Hazardous Substances Data)

Upstream product

• 1004-39-3 4,6-diaminopyrimidine-2(1H)-thione 
• 1004-39-3 4,6-diamino-2-mercaptopyrimidine 

Downstream Products

• 5468-67-7 4,6-diaminopyrimidine hydrochloride 

Relevant articles and documents

Method for synthesis of adenine (by machine translation)

The invention discloses a synthetic method for adenine. Malononitrile and thiourea are employed as raw materials. The raw materials are subjected to a cyclization reaction under action of sodium alkoxide, and 4,6-diamino-2-sulfydryl pyrimidine. Then through three reaction routes, adenine is obtained. Though the method has many reaction steps, no refining or drying are needed for the product of each reaction step, the product can be used in the next reaction step, and the operation is simple. The raw materials are easily available, the prices are relatively low, the reaction conditions are mild, the operation is simple, the reaction steps are decreased, the reaction time is shortened, the overall reaction yield is high, and the synthetic method is suitable for industrial production.

Nucleosides part LXVI I[1]: Synthesis of 4-amino-7(8H) pteridinone-N8-nucleosides-structural analogs of adenosine

Various 4-amino-7(8H)pteridones (6, 12, 14, 15, 20, 22) have been glycosylated with 1-chloro-2'-deoxy-D-ribofuranose derivatives (25, 26) applying the new DBU-salt method to form the N8-2'-deoxy-D-ribofuranosides (27-36) which can be regarded as 2'-deoxyadenosine analogs. Analogously reacted the 2-N,N-dimethyl-amino-methyleneimino-7(8H)pteridones (43-48) to give preferentially the corresponding N8-ss-D-anomers (49-55). Ribosylation with 1-bromo-2,3,5-tri-O-benzoyl-a-D-ribofuranose (56) proceeded as well with 6, 12, 15, 45, and 46 to yield to N8-ss-D-ribofuranosides 57-61. Sugar deprotection led to the free N8-2'-deoxy-ss-D-ribofuranosides 37-42 and N8-ss-D-ribofurano-sides 62-65, respectively. Glycosylations via the silyl-method under Vorbruggen conditions led with 6, 12 and 15 to the same results, however, 4-amino-6-phenyl-7(8H)pteridone (14) reacted differently forming the N1-ss-D-ribofuranosides (71, 79) and the N1-2'-deoxy - and ss-D-ribofuranosides 73, 74, 77, 78. The assignments of the structures have been achieved by 1H-NMR- and UV-spectra. C,H,N-elemental analyses account for the composition.

Pteridine nucleotide analogs as fluorescent DNA probes

The invention provides novel pteridine nucleotides which are highly fluorescent under physiological conditions and which may be used in the chemical synthesis of fluorescent oligonucleotidcs. The invention further provides for fluorescent oligonucleotides comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures.