5468-67-7

Basic information

• Product Name: pyrimidine-4,6-diamine hydrochloride
• Synonyms: pyrimidine-4,6-diamine hydrochloride
• CAS NO: 5468-67-7
• Molecular Formula: C₄H₆N₄*ClH
• Molecular Weight: 146.57818
• EINECS: 226-788-8
• Mol File: 5468-67-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 364 °C at 760 mmHg
• Flash Point: 201.5 °C
• Appearance: /
• Vapor Pressure: 1.73E-05mmHg at 25°C
• CAS DataBase Reference: pyrimidine-4,6-diamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: pyrimidine-4,6-diamine hydrochloride(5468-67-7)
• EPA Substance Registry System: pyrimidine-4,6-diamine hydrochloride(5468-67-7)

Safety Data

• Hazardous Substances Data: 5468-67-7(Hazardous Substances Data)

Usage

General Description

Pyrimidine-4,6-diamine hydrochloride, also known as 4,6-diamino-2-pyrimidinamine hydrochloride, is a chemical compound with the molecular formula C4H7N5?HCl. It is a derivative of pyrimidine and is commonly used in the synthesis of various pharmaceuticals and organic compounds. It is a white to off-white crystalline powder that is soluble in water and is stable under normal conditions. Pyrimidine-4,6-diamine hydrochloride has a wide range of applications, including as a building block for the synthesis of anticancer drugs and as a key intermediate in the production of various organic compounds. Its properties make it an important chemical in the field of medicinal chemistry and organic synthesis.

InChI:InChI=1/C4H6N4.ClH/c5-3-1-4(6)8-2-7-3;/h1-2H,(H4,5,6,7,8);1H

Upstream product

• 40070-06-2 4,6-diaminopyrimidine-2-sulfinic acid 

Downstream Products

• 61908-15-4 4,6-diamino-5-nitrosylpyrimidine 
• 1064577-87-2 N₄-((8-chloro-2-(2-chlorophenyl)quinolin-3-yl)-methyl)pyrimidine-4,6-diamine 

Relevant articles and documents

Nucleosides part LXVI I[1]: Synthesis of 4-amino-7(8H) pteridinone-N8-nucleosides-structural analogs of adenosine

Various 4-amino-7(8H)pteridones (6, 12, 14, 15, 20, 22) have been glycosylated with 1-chloro-2'-deoxy-D-ribofuranose derivatives (25, 26) applying the new DBU-salt method to form the N8-2'-deoxy-D-ribofuranosides (27-36) which can be regarded as 2'-deoxyadenosine analogs. Analogously reacted the 2-N,N-dimethyl-amino-methyleneimino-7(8H)pteridones (43-48) to give preferentially the corresponding N8-ss-D-anomers (49-55). Ribosylation with 1-bromo-2,3,5-tri-O-benzoyl-a-D-ribofuranose (56) proceeded as well with 6, 12, 15, 45, and 46 to yield to N8-ss-D-ribofuranosides 57-61. Sugar deprotection led to the free N8-2'-deoxy-ss-D-ribofuranosides 37-42 and N8-ss-D-ribofurano-sides 62-65, respectively. Glycosylations via the silyl-method under Vorbruggen conditions led with 6, 12 and 15 to the same results, however, 4-amino-6-phenyl-7(8H)pteridone (14) reacted differently forming the N1-ss-D-ribofuranosides (71, 79) and the N1-2'-deoxy - and ss-D-ribofuranosides 73, 74, 77, 78. The assignments of the structures have been achieved by 1H-NMR- and UV-spectra. C,H,N-elemental analyses account for the composition.