400750-34-7

Basic information

• Product Name: 2-(1H-pyrazol-1-yl) benzoic acid methyl ester
• Synonyms: 2-(1H-pyrazol-1-yl) benzoic acid methyl ester
• CAS NO: 400750-34-7
• Molecular Weight: 202.213
• Mol File: 400750-34-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(1H-pyrazol-1-yl) benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-pyrazol-1-yl) benzoic acid methyl ester(400750-34-7)
• EPA Substance Registry System: 2-(1H-pyrazol-1-yl) benzoic acid methyl ester(400750-34-7)

Safety Data

• Hazardous Substances Data: 400750-34-7(Hazardous Substances Data)

Upstream product

• 288-13-1 NH-pyrazole 
• 394-35-4 methyl 2-fluorobenzoate 
• 124-38-9 carbon dioxide 
• 1126-00-7 1-phenylpyrazole 
• 6063-88-3 methoxydimethylaluminium 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 55317-53-8 2-(1H-pyrazol-1-yl)benzoic acid 
• 13939-06-5 molybdenum hexacarbonyl 
• 74-88-4 methyl iodide 

Downstream Products

• 741717-59-9 (2-(1H-pyrazol-1-yl)phenyl)methanol 
• 1026532-14-8 2-[2-(2-Pyrazol-1-yl-benzylsulfanyl)-imidazol-1-yl]-pyridine 

Relevant articles and documents

Palladium-Catalyzed Oxidative Carbonylation of Aromatic C?H Bonds with Alcohols using Molybdenum Hexacarbonyl as the Carbon Monoxide Source

With molybdenum hexacarbonyl as the carbon monoxide source, a general palladium-catalyzed carbonylative transformation of the C?H bond on aromatic rings to produce esters has been developed. Good yields of the corresponding products have been obtained with wide functional group tolerance and excellent regioselectivity. A variety of aliphatic alcohols are suitable reactants here. (Figure presented.).

Ruthenium-catalyzed c-h silylation of 1-arylpyrazole derivatives and fluoride-mediated carboxylation: Use of two nitrogen atoms of the pyrazole Group

Carboxylation of 1-arylpyrazole derivatives was developed using a ruthenium-catalyzed ortho silylation in conjunction with fluoride-mediated carboxylation with carbon dioxide. The two nitrogen atoms of pyrazole play crucial roles in promoting ortho silylation via the formation of a five-membered ruthenacycle and in accelerating aryl anion formation by lowering the electron density of the aromatic ring. Georg Thieme Verlag Stuttgart New York.

2-[(2-Aminobenzyl)sulfinyl]-1-(2-pyridyl)-1,4,5,6- tetrahydrocyclopent[d]imidazoles as a novel class of gastric H+/K+-ATPase inhibitors

Substituted 2-sulfinylimidazoles were synthesized and investigated as potential inhibitors of gastric H+/K+-ATPase. The 4,5-unsubstituted imidazole series 6-11 and the 1,4,5,6-tetrahydrocyclopent[d]imidazole series 12 were found to be potent inhibitors of the acid secretory enzyme H+/K+- ATPase. Structure-activity relationships indicate that the substitution of 2- pyridyl groups at the 1-position of the imidazole moiety combined with (2- aminobenzyl)sulfinyl groups at the 2-position leads to highly active compounds with a favorable chemical stability. Other substitution patterns in the imidazole moiety result in reducing biological activities. 2-[(2- Aminobenzyl)sulfinyl]-1-[2-(3-methylpyridyl)]-1,4,5,6- tetrahydrocyclopent[d]imidazole (12h, T-776) was selected for further development as a potential clinical candidate. Extensive study on the acid degradation of 12h indicates a mechanism of action different from that of omeprazole, the first H+/K+-ATPase inhibitor introduced to the market.