400770-59-4Relevant academic research and scientific papers
3-Amino-1-alkyl-cyclopentane carboxamides as small molecule antagonists of the human and murine CC chemokine receptor 2
Butora, Gabor,Jiao, Richard,Parsons, William H.,Vicario, Pasquale P.,Jin, Hong,Ayala, Julia M.,Cascieri, Margaret A.,Yang, Lihu
, p. 3636 - 3641 (2007)
A series of low molecular weight antagonists of both the human and murine CC chemokine receptor 2, containing a 1-alkyl-3-(3-methyl-4-spiroindenylpiperidine)-substituted cyclopentanecarboxamide, is described. A SAR study of the C1 substituent r
Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists
Yang, Lihu,Butora, Gabor,Jiao, Richard X.,Pasternak, Alex,Zhou, Changyou,Parsons, William H.,Mills, Sander G.,Vicario, Pasquale P.,Ayala, Julia M.,Cascieri, Margaret A.,MacCoss, Malcolm
, p. 2609 - 2611 (2008/02/05)
Introduction of ring restrictions to a linear aminobutyramide CC chemokine receptor 2 (CCR2) antagonist lead (2) led to the discovery of a 1,3-disubstituted cyclopentane scaffold with enhanced hCCR2 receptor binding and antagonist activity. (1S,3R)-N-[3,5
