400785-59-3

Basic information

• Product Name: 4-benzyl-piperazine-1-N,N'-bis(tert-butoxycarbonyl)carboxamidine
• Synonyms: 4-benzyl-piperazine-1-N,N'-bis(tert-butoxycarbonyl)carboxamidine
• CAS NO: 400785-59-3
• Molecular Weight: 418.536
• Mol File: 400785-59-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-benzyl-piperazine-1-N,N'-bis(tert-butoxycarbonyl)carboxamidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyl-piperazine-1-N,N'-bis(tert-butoxycarbonyl)carboxamidine(400785-59-3)
• EPA Substance Registry System: 4-benzyl-piperazine-1-N,N'-bis(tert-butoxycarbonyl)carboxamidine(400785-59-3)

Safety Data

• Hazardous Substances Data: 400785-59-3(Hazardous Substances Data)

Upstream product

• 2759-28-6 1-phenylmethylpiperazine 
• 145013-05-4 tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate 

Downstream Products

• 7773-69-5 4-benzylpiperazine-1-carboximidamide 

Relevant articles and documents

A novel, facile methodology for the synthesis of N,N′-bis(tert-butoxycarbonyl)-protected guanidines using polymer-supported carbodiimide

A novel methodology for the synthesis of guanidines from amines has been developed using polymer assisted synthesis, potentially allowing the preparation of series of compounds in a high throughput manner. The methodology comprises the use of polymer-supported carbodiimide as the activating agent for N,N′-bis(tert-butoxycarbonyl) thiourea with polymer-supported trisamine as a scavenger, followed by deprotection with trifluoroacetic acid. For the first time, polymer-supported carbodiimide has been utilized as an activating agent to synthesize guanidines.