7773-69-5

Basic information

• Product Name: 4-BENZYLPIPERAZINE-1-CARBOXAMIDINE HEMISULFATE
• Synonyms: 4-BENZYLPIPERAZINE-1-CARBOXAMIDINE HEMISULFATE;4-BENZYLPIPERAZINE-1-CARBOXAMIDINEHEMISULPHATE;1-benzyl-4-(guanidinoiminomethyl)piperazine;4-benzyl-1-piperazinecarboxamidin;4-BENZYLPIPERAZINE-1-CARBOXAMIDINE HEMISULFATE >98%;1-PiperazinecarboxiMidaMide, 4-(phenylMethyl)-;4-Benzylpiperazine-1-carboximidamide sulfate;4-(phenylmethyl)piperazine-1-carboximidamide
• CAS NO: 7773-69-5
• Molecular Formula: C₁₂H₁₈N₄
• Molecular Weight: 316.38
• Mol File: 7773-69-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 238-240°C
• Boiling Point: 332.8 °C at 760 mmHg
• Flash Point: 155.1 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 0.000142mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: 4-BENZYLPIPERAZINE-1-CARBOXAMIDINE HEMISULFATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BENZYLPIPERAZINE-1-CARBOXAMIDINE HEMISULFATE(7773-69-5)
• EPA Substance Registry System: 4-BENZYLPIPERAZINE-1-CARBOXAMIDINE HEMISULFATE(7773-69-5)

Safety Data

• Hazardous Substances Data: 7773-69-5(Hazardous Substances Data)

Usage

General Description

4-Benzylpiperazine-1-carboxamidine hemisulfate is a chemical compound that is commonly used in research and testing procedures. It is a hemisulfate salt derivative of the molecular compound benzylpiperazine, which is known for its psychoactive properties. The carboxamidine group attached to the piperazine ring enhances its pharmacological and biological activities, making it a valuable tool in medicinal chemistry studies. 4-BENZYLPIPERAZINE-1-CARBOXAMIDINE HEMISULFATE has been studied for its potential in treating various neurological disorders and as a precursor for the synthesis of new drug candidates. Its hemisulfate form enhances its solubility and stability, making it a versatile and valuable tool in scientific research and drug development.

InChI:InChI=1/C12H18N4/c13-12(14)16-8-6-15(7-9-16)10-11-4-2-1-3-5-11/h1-5H,6-10H2,(H3,13,14)

Upstream product

• 400785-59-3 4-benzyl-piperazine-1-N,N'-bis(tert-butoxycarbonyl)carboxamidine 
• 2759-28-6 1-phenylmethylpiperazine 
• 867-44-7 S-Methylisothiourea sulfate 

Downstream Products

• 845616-57-1 2-(4-benzyl-piperazin-1-yl)-5-trifluoromethyl-pyrimidine 
• 7761-69-5 1-benzyl-4-carbamimidoyl-1-methyl-piperazinium; iodide hydriodide 
• 1133784-12-9 Methyl 2-(4-benzylpiperazin-1-yl)pyrimidine-5-carboxylate 

Relevant articles and documents

Synthesis and antitumor activities of a new series of 4,5-dihydro-1H- thiochromeno[4,3-d]pyrimidine derivatives

A new series of 4,5-dihydro-1H-thiochromeno[4,3-d ]pyrimidine derivatives have been designed and synthesized. The antitumor activities of the target compounds have been evaluated in vitro against two human cancer cell lines including A549 (human alveolar adenocarcinoma cell) and H460 (human lung cancer) by MTT assay. Most of the target compounds exhibited significant antitumor activities against A549 and H460 cancer cell lines. The most potent compound 4-(benzo[d][1,3]dioxol-5-yl)-8,9-difluoro-2-(4-methylpiperazin-1-yl)-4, 5-dihydro-1H-thiochromeno[4,3-d]pyrimidine (CH05) (IC50 = 0.44 μM, 3.07 μM) was 2.0 and 8.4 times more active than gefitinib (IC50 = 0.89 μM, 16.81 μM) against A549 and H460 cell lines, respectively.