400835-47-4

Upstream product

• 100-39-0 benzyl bromide 
• 163125-34-6 1,1,2,2-tetramethoxycyclohexane 
• 171192-29-3 (1R,3R,4S,4aR,8aS,9aR,10aS)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-3-ethylsulfanyl-8a,10a-dimethoxy-decahydro-2,9,10-trioxa-anthracen-4-ol 
• 400835-46-3 ((1R,3R,4S,4aS,8aS,9aR,10aS)-4-Benzyloxy-3-ethylsulfanyl-8a,10a-dimethoxy-decahydro-2,9,10-trioxa-anthracen-1-ylmethoxy)-tert-butyl-diphenyl-silane 
• 7473-36-1 ethyl 1-thio-α-D-mannopyranoside 
• 163125-38-0 (1'S,2'S)-Ethyl 3,4-O-(1',2'-dimethoxycyclohexane-1',2'-diyl)-1-thio-α-D-mannopyranoside 
• 78-77-3 Isobutyl bromide 
• 189105-30-4 ethyl-2-O-benzyl-3,4-O-[1',2'-dimethoxycyclohexan-1',2'-diyl]-1-thio-α-D-mannopyranoside 

Downstream Products

• 400835-48-5 (2R,3S,4S,5S,6R)-5-Benzyloxy-6-ethylsulfanyl-2-isobutoxymethyl-tetrahydro-pyran-3,4-diol 

Relevant academic research and scientific papers

Synthesis and Structure - Activity Relationship of Mannose-Based Peptidomimetics Selectively Blocking Integrin α4β7 Binding to Mucosal Addressin Cell Adhesion Molecule-1

As part of our ongoing research in the development of α4β7 integrin antagonists, we are interested in peptidomimetics based on a rigid scaffold to allow the display of essential side chains in a suitable binding conformation while eliminating backbone ami

Design, synthesis, and biological evaluation of α4β1 integrin antagonists based on β-D-mannose as rigid scaffold

A cyclic peptide role model was used for the design and synthesis of a new class of biologically active and α4-selective integrin antagonists (e.g. 1) based on β-D-mannose. These carbohydrate-based peptidomimetics were synthesized to include th