400899-08-3

Basic information

• Product Name: tert-butyl ((1r,4r)-4-(hydroxymethyl)cyclohexyl)(methyl)carbamate
• Synonyms: tert-butyl ((1r,4r)-4-(hydroxymethyl)cyclohexyl)(methyl)carbamate
• CAS NO: 400899-08-3
• Molecular Weight: 243.346
• Mol File: 400899-08-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: tert-butyl ((1r,4r)-4-(hydroxymethyl)cyclohexyl)(methyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl ((1r,4r)-4-(hydroxymethyl)cyclohexyl)(methyl)carbamate(400899-08-3)
• EPA Substance Registry System: tert-butyl ((1r,4r)-4-(hydroxymethyl)cyclohexyl)(methyl)carbamate(400899-08-3)

Safety Data

• Hazardous Substances Data: 400899-08-3(Hazardous Substances Data)

Upstream product

• 400899-07-2 methyl (1r,4r)‐4‐{[(tert‐butoxy)carbonyl](methyl)amino}cyclohexane‐1‐carboxylate 
• 146307-51-9 methyl (1R,4R)-4-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate 
• 53292-90-3 trans-4-(tert-butoxycarbonylamino)cyclohexanoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 62456-15-9 methyl trans-4-amino-cyclohexanecarboxylate 

Downstream Products

• 400899-17-4 methanesulfonic acid 5-[4-(tert-butoxycarbonyl-methyl-amino)-cyclohexyl]-pentyl ester 
• 400899-16-3 [4-(5-hydroxy-pentyl)-cyclohexyl]-methyl-carbamic acid tert-butyl ester 
• 400899-10-7 3-[4-(tert-butoxycarbonyl-methyl-amino)-cyclohexyl]-propionic acid ethyl ester 
• 400899-11-8 [4-(3-hydroxy-propyl)-cyclohexyl]-methyl-carbamic acid tert-butyl ester 
• 400899-12-9 methyl-[4-(3-oxo-propyl)-cyclohexyl]-carbamic acid tert-butyl ester 
• 400898-94-4 trans-(4-formylcyclohexyl)methylcarbamic acid tert-butyl ester 

Relevant articles and documents

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety capable of binding to IRAK4 and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.

Oxidosqualene cyclase (OSC) inhibitors for the treatment of dyslipidemia

Novel inhibitors of oxidosqualene cyclase (OSC) for the treatment of dyslipidemia are reported. Starting point for the chemistry program was a set of compounds derived from a fungicide project which, in addition to high affinity for OSC from Candida albicans, also showed high affinity for the human enzyme (hOSC). Here the evaluation process of different scaffolds is outlined for two representative series, the phenyl substituted benzo[d]isothiazoles and the aminocyclohexanes. The most promising compounds derived from the latter series were further profiled in vivo and showed promising properties with respect to modulation of lipid parameters. Schweizerische Chemische Gesellschaft.