40110-96-1

Basic information

• Product Name: 4'-benzyloxy-5,6,7,8-tetramethoxyflavone
• Synonyms: 4'-benzyloxy-5,6,7,8-tetramethoxyflavone
• CAS NO: 40110-96-1
• Molecular Weight: 448.472
• Mol File: 40110-96-1.mol

Chemical Properties

• CAS DataBase Reference: 4'-benzyloxy-5,6,7,8-tetramethoxyflavone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-benzyloxy-5,6,7,8-tetramethoxyflavone(40110-96-1)
• EPA Substance Registry System: 4'-benzyloxy-5,6,7,8-tetramethoxyflavone(40110-96-1)

Safety Data

• Hazardous Substances Data: 40110-96-1(Hazardous Substances Data)

Upstream product

• 1486-50-6 4-(benzyloxy)benzoic acid chloride 
• 85374-52-3 1-(4-benzyloxyphenyl)-3-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)propane-1,3-dione 
• 1350827-37-0 2-(4-benzyloxybenzoyloxy)-3,4,5,6-tetramethoxyacetophenone 
• 40110-95-0 4-benzyloxy-2'-hydroxy-3',4',5',6'-tetramethoxychalcone 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 481-53-8 tangeritin 
• 3162-28-5 2-hydroxy-3,4,5,6-tetramethoxyacetophenone 
• 40110-95-0 2'-Hydroxy-3'.4'.5'.6'-tetramethoxy-4-benzyloxy-chalkon 
• 73898-14-3 4'-benzyloxy-5,6,7,8-tetramethoxyflavanone 

Downstream Products

• 481-53-8 tangeritin 
• 16545-23-6 xanthomicrol 
• 2798-20-1 gardenin B 
• 6959-55-3 Acetic acid 4-(5,6,7,8-tetramethoxy-4-oxo-4H-chromen-2-yl)-phenyl ester 
• 36950-98-8 4'-hydroxy-5,6,7,8-tetramethoxy flavone 

Relevant articles and documents

B-Ring-modified and/or 5-demethylated nobiletin congeners: Inhibitory activity against pro-MMP-9 production

Three metabolites and 12 analogues of nobiletin (1) were synthesized. Whereas nobiletin derivatives 2-4 inhibited pro-MMP-9 production similarly in both PMA- and TNF-α-stimulated human lens epithelial cells, the 2′-hydroxylated analogue 5a exerted marked inhibitory effects (IC 50: 0.4 μM) on PMA-treated cells, which were 170-fold more potent than those on TNF-α-treated cells. This activity may be closely related to PKC-mediated transcriptional regulation of pro-MMP-9.

Biotransformation of polymethoxylated flavonoids: Access to their 4′-O-demethylated metabolites

Regioselective O-demethylation of the flavones tangeretin (1) and 3-hydroxytangeretin (6) into their 4′-O-demethylated metabolites was performed by using an Aspergillus niger strain. This method serves as a straightforward alternative to multistep synthes

Inhibitor of aldose reductase

An inhibitor of aldose reductase which contains, as the effective ingredient, a flavone derivative having the following formula: STR1 wherein R1 is hydrogen atom or hydroxyl group, R2 is hydroxyl group or methoxyl group or a pharmace