85374-52-3

Basic information

• Product Name: 1-(4-benzyloxyphenyl)-3-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)propane-1,3-dione
• Synonyms: 1-(4-benzyloxyphenyl)-3-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)propane-1,3-dione
• CAS NO: 85374-52-3
• Molecular Weight: 466.488
• Mol File: 85374-52-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-benzyloxyphenyl)-3-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)propane-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-benzyloxyphenyl)-3-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)propane-1,3-dione(85374-52-3)
• EPA Substance Registry System: 1-(4-benzyloxyphenyl)-3-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)propane-1,3-dione(85374-52-3)

Safety Data

• Hazardous Substances Data: 85374-52-3(Hazardous Substances Data)

Upstream product

• 3162-28-5 2-hydroxy-3,4,5,6-tetramethoxyacetophenone 
• 1486-50-6 4-(benzyloxy)benzoic acid chloride 
• 1350827-37-0 2-(4-benzyloxybenzoyloxy)-3,4,5,6-tetramethoxyacetophenone 

Downstream Products

• 40110-96-1 4'-benzyloxy-5,6,7,8-tetramethoxyflavone 
• 36950-98-8 4'-hydroxy-5,6,7,8-tetramethoxy flavone 
• 16545-23-6 xanthomicrol 
• 481-53-8 tangeritin 

Relevant articles and documents

B-Ring-modified and/or 5-demethylated nobiletin congeners: Inhibitory activity against pro-MMP-9 production

Three metabolites and 12 analogues of nobiletin (1) were synthesized. Whereas nobiletin derivatives 2-4 inhibited pro-MMP-9 production similarly in both PMA- and TNF-α-stimulated human lens epithelial cells, the 2′-hydroxylated analogue 5a exerted marked inhibitory effects (IC 50: 0.4 μM) on PMA-treated cells, which were 170-fold more potent than those on TNF-α-treated cells. This activity may be closely related to PKC-mediated transcriptional regulation of pro-MMP-9.