40117-29-1

Basic information

• Product Name: N-[(4-Methylphenyl)methylene]-2-methyl-2-propanamine N-oxide
• Synonyms: N-(4-Methylbenzylidene)-1,1-dimethylethanamine N-oxide;N-(4-Methylbenzylidene)-tert-butylamine N-oxide;N-[(4-Methylphenyl)methylene]-2-methyl-2-propanamine N-oxide;N-tert-Butyl-4-methylbenzenemethanimine N-oxide
• CAS NO: 40117-29-1
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 0
• Mol File: 40117-29-1.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-[(4-Methylphenyl)methylene]-2-methyl-2-propanamine N-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(4-Methylphenyl)methylene]-2-methyl-2-propanamine N-oxide(40117-29-1)
• EPA Substance Registry System: N-[(4-Methylphenyl)methylene]-2-methyl-2-propanamine N-oxide(40117-29-1)

Safety Data

• Hazardous Substances Data: 40117-29-1(Hazardous Substances Data)

Upstream product

• 55980-45-5 N-(4′-methylbenzyl)-2-methylpropan-2-amine 
• 16649-50-6 N-tert-Butylhydroxylamine 
• 104-87-0 4-methyl-benzaldehyde 
• 594-70-7 2-Methyl-2-nitropropane 
• 57497-39-9 N-tertbutylhydroxylamine hydrochloride 
• 86401-98-1 N-(tert-butyl)-N-(4-methyl-benzylidene)-amine 
• 67425-83-6 2-tert-butyl-3-p-tolyl-oxaziridine 
• 139-66-2 diphenyl sulfide 

Downstream Products

• 54078-56-7 C₁₈H₂₂NO 
• 65908-32-9 5-methyl-2,3-diphenyl-1H-inden-1-one 
• 1383738-67-7 (S)-2-tert-butyl-5-phenyl-3-p-tolyl-2,3-dihydroisoxazole-4-carbaldehyde 
• 1346238-44-5 (E)-N-(3-(cyclohex-1-en-1-yl)-1-(p-tolyl)prop-2-yn-1-ylidene)-2-methylpropan-2-amine oxide 

Relevant articles and documents

Method for preparing nitrone from secondary amine

The invention relates to a method for preparing nitrone from secondary amine. The method comprises the steps of adding 2 mmol of the secondary amine into a reactor, sequentially adding 4-5 mL of water, 0.02-0.03 mmol of tetrabutylammonium bromide, 0.02-0.08 mmol of a catalyst WO3-x and 3-6 mmol of a hydrogen peroxide solution with the concentration being 30-50%, and stirring the mixture for 2-6 hours at the temperature of 25-60 DEG C; or adding 2 mmol of the secondary amine into a reactor, adding 3-5 mL of polar solvent, 0.02-0.08 mmol of a catalyst WO3-x ad 3-6 mmol of a hydrogen peroxide solution with the concentration being 30-50%, and stirring the mixture for 2-6 hours at the temperature of 25-60 DEG C; diluting a mixed solution obtained after a reaction to 15-20 mL, conducting extraction, concentration and column chromatography isolation, and collecting a product. The catalyst adopted in the method is WO3-x nanosheets having oxygen vacancies and is high in catalytic oxidation activity; raw materials of the method are wide in source, the reaction condition is simple, the reaction temperature is low, the nitrone yield is high, and water serves as reaction solvent, so that the whole reaction steps are free of pollution, environmentally friendly and low in cost, high industrial application value is achieved, and in addition, great environmental and social significance is achieved.

PBN (phenyl-N-tert-butylnitrone)-derivatives are effective in slowing the visual cycle and rhodopsin regeneration and in protecting the retina from light-induced damage

A2E and related toxic molecules are part of lipofuscin found in the retinal pigment epithelial (RPE) cells in eyes affected by Stargardt's disease, age-related macular degeneration (AMD), and other retinal degenerations. A novel therapeutic approach for t

COMPOSITIONS AND METHODS OF INHIBITING RETINAL DEGENERATION

Nitrone-based compositions are disclosed that may be utilized for the prevention and treatment of a variety of ophthalmic diseases or conditions where RPE65 protein isomerohydrolase is implicated. Methods of production and use of said nitrone-based compos