128648-56-6

Basic information

• Product Name: 2-(1,3-dioxoisoindolin-2-yl)ethyl methanesulfonate
• CAS NO: 128648-56-6
• Molecular Weight: 269.278
• Mol File: 128648-56-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(1,3-dioxoisoindolin-2-yl)ethyl methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1,3-dioxoisoindolin-2-yl)ethyl methanesulfonate(128648-56-6)
• EPA Substance Registry System: 2-(1,3-dioxoisoindolin-2-yl)ethyl methanesulfonate(128648-56-6)

Safety Data

• Hazardous Substances Data: 128648-56-6(Hazardous Substances Data)

Usage

Molecular weight

295.3

Chemical class

Sulfonate ester

Uses

Intermediate in the production of pharmaceuticals and agrochemicals, synthesis of various organic compounds

Stability

Stable under normal storage conditions

Handling and usage

Should be handled and used in a laboratory setting with proper safety precautions and in accordance with safety regulations and guidelines due to potential health and environmental hazards.

Upstream product

• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 
• 124-63-0 methanesulfonyl chloride 
• 85-44-9 phthalic anhydride 

Downstream Products

• 40149-83-5 2-(2-iodoethyl)isoindoline-1,3-dione 
• 98395-64-3 N-(2-ortho-nitrophenoxyethyl)phthalimide 

Relevant articles and documents

Facile synthesis of indolizinoindolone, indolylepoxypyrrolooxazole, indolylpyrrolooxazolone and isoindolopyrazinoindolone heterocycles from indole and imide derivatives

Chemo-, regio- and diastereoselective coupling reactions of indole with imide derivatives leading to unique heterocyclic systems are demonstrated. Acid-induced 3-position coupling reactions of indole with cyclic imide derived lactamols followed by acid promoted 2-position cyclizations with the corresponding aldehydes are described to obtain the indolizinoindolones and benzoindolizinoindolones. Base induced 2-position coupling reactions ofN-tosylindole withN-(2-iodoethyl)imides and the subsequent cyclizations provide indolylepoxypyrrolooxazole, indolylpyrrolooxazolone and indolyloxazoloisoindolone. Reductive cleavage of indolyloxazoloisoindolone to the corresponding alcohol followed by mesylation and base promotedN-cyclization affords thein situair-oxidized pentacyclic product hydroxyisoindolopyrazinoindolone. A regioisomeric structural revision of the natural product from 1,2,5,6,7,11c-hexahydro-3H-indolizino[7,8-b]indol-3-one to 1,2,5,6,11,11b-hexahydro-3H-indolizino(8,7-b)indol-3-one is also reported in the present studies focussed on the methodologies for heterocyclic synthesis.