4015-31-0Relevant academic research and scientific papers
DIAMINOTHIAZOLES USEFUL AS AXL INHIBITORS
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Page/Page column 49, (2008/12/07)
Diaminothiazoles and pharmaceutical compositions containing them are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the diaminothiazoles in treating diseases or conditions associated with Axl activity are also disclosed.
Synthesis of condensed quinolines and quinazolines as DNA ligands
Malecki, Natacha,Carato, Pascal,Rigo, Benoit,Goossens, Jean-Francois,Houssin, Raymond,Bailly, Christian,Henichart, Jean-Pierre
, p. 641 - 647 (2007/10/03)
Among new condensed quinolines and quinazolines the design of which were inspired by anti-cancer DNA-binding alkaloids such as camptothecin and batracyclin, DNA binding tests identify the 8-methoxy-7- piperazinylpropoxyindeno[1,2-b]quinolin-11-one tetracyclic system as a new motif for DNA recognition.
o-Aminophenyl Alkyl/Aralkyl Ketones and Their Derivatives: Part V -- An Efficient Synthetic Route to Some Biologically Active 4-Substituted Quinazolines
Byford, A.,Goadby, P.,Hooper, M.,Kamath, H. V.,Kulkarni, Sheshgiri N.
, p. 396 - 397 (2007/10/02)
4-Substituted quinazolines (II) have been prepared by the action of formamide on o-aminophenyl alkyl and aralkyl ketones (I) in the presence of borontrifluoride etherate as catalyst, and tested for their inotropic activity.
